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• W1995487921 abstract "In this study, the measurement both of peripheral gonadotropins (FSH and LH) and of sex steroids in male and female wild anuran, Rana esculenta, was performed during the annual reproductive cycle; moreover, the role of gonadotropins in the vitellogenic process and in ovarian steroidogenesis was investigated through in vitro experiments. LH plasma changes in males showed high values during autumn-winter months and during the mating period, when high androgen levels were found. Conversely, for the first time in male vertebrates, a clear correspondence between plasma FSH and estradiol-17β (E2) was shown. In females, FSH peak values were found at the beginning of the mating period in parallel with those of plasma vitellogenin (VTG) and E2; in contrast, high LH levels went together with ovarian weight (gonadosomatic index), which is considered a good marker for the plasma sequestration of VTG by growing oocytes. The in vivo results are corroborated by in vitro studies showing the direct effects of both FSH and LH in inducing hepatic VTG synthesis and release in the culture media. Lastly, although it is not yet known whether or not FSH and LH have separate functions in amphibians, it was clearly shown that they induce ovarian steroid production. These results are discussed in terms of the high seasonality previously demonstrated in this wild frog." @default.
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• W1995487921 date "1998-01-01" @default.
• W1995487921 modified "2023-10-02" @default.
• W1995487921 title "Gonadotropins and Reproductive Function in the Anuran Amphibian, Rana Esculenta 1" @default.
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• W1995487921 doi "https://doi.org/10.1095/biolreprod58.1.88" @default.
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