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• W1995493721 endingPage "2189" @default.
• W1995493721 startingPage "2181" @default.
• W1995493721 abstract "We examined whether plasmids encoding granulocyte-macrophage colony-stimulating factor (pGM-CSF) or CD40-ligand (pCD40L) could modify the immune response to antigen encoded by co-injected plasmid DNA. For this we used as antigen Escherichia coli beta galactosidase (beta-gal), encoded by the plasmid pLacZ. We found that intradermal co-injection of pLacZ with both pGM-CSF and pCD40L enhanced the anti-beta-gal IgG response by approximately two orders of magnitude compared to injections of pLacZ alone. Co-injection of both pGM-CSF and pCD40L with pLacZ significantly enhanced antigen-specific IgG, and in particular IgG(2a), over that of animals co-injected with pLacZ and either pGM-CSF or pCD40L. We found that co-injection of pGM-CSF and pCD40L with pLacZ enhanced the generation of beta-gal-specific cytotoxic T cells, and allowed for a significant expansion of CD8(+) T cells from splenocytes co-cultured with beta-gal expressing stimulator cells. The immunostimulatory effects induced by pGM-CSF or pCD40L required injection of these plasmids to the same site that received pLacZ. 'Priming' experiments, where the site of injection was pre-injected with either plasmid adjuvant, showed that pGM-CSF, but not pCD40L, could enhance the anti-beta-gal immune response induced by subsequently administered plasmid antigen. We conclude that plasmids encoding GM-CSF and CD154 are particularly effective genetic adjuvants when used together to enhance the humoral and cellular immune response to a plasmid-encoded antigen." @default.
• W1995493721 created "2016-06-24" @default.
• W1995493721 creator A5001781831 @default.
• W1995493721 creator A5036828560 @default.
• W1995493721 creator A5058755419 @default.
• W1995493721 date "2001-02-01" @default.
• W1995493721 modified "2023-10-11" @default.
• W1995493721 title "Plasmids encoding granulocyte–macrophage colony-stimulating factor and CD154 enhance the immune response to genetic vaccines" @default.
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• W1995493721 doi "https://doi.org/10.1016/s0264-410x(00)00382-0" @default.
• W1995493721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11228391" @default.
• W1995493721 hasPublicationYear "2001" @default.
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