FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995494147> ?p ?o ?g. }

• W1995494147 endingPage "233" @default.
• W1995494147 startingPage "228" @default.
• W1995494147 abstract "Abstract Immunization with adenovirus expressing the TSH receptor (TSHR) induces hyperthyroidism in 25–50% of mice. Even more effective is immunization with a TSHR A-subunit adenovirus (65–84% hyperthyroidism). Nevertheless, TSHR antibody characteristics in these mice do not mimic accurately those of autoantibodies in typical Graves’ patients, with a marked TSH-blocking antibody response. We hypothesized that this suboptimal antibody response was consequent to the standard dose of TSHR-adenovirus providing too great an immune stimulus. To test this hypothesis, we compared BALB/c mice immunized with the usual number (1011) and with far fewer viral particles (109 and 107). Regardless of viral dose, hyperthyroidism developed in a similar proportion (68–80%) of mice. We then examined the qualitative nature of TSHR antibodies in each group. Sera from all mice had TSH binding-inhibitory (TBI) activity after the second immunization, with TBI values in proportion to the viral dose. After the third injection, all groups had near-maximal TBI values. Remarkably, in confirmation of our hypothesis, immunization with progressively lower viral doses generated TSHR antibodies approaching the characteristics of autoantibodies in human Graves’ disease as follows: 1) lower TSHR antibody titers on ELISA and 2) lower TSH-blocking antibody activity without decrease in thyroid-stimulating antibody activity. In summary, low-dose immunization with adenovirus expressing the free TSHR A-subunit provides an induced animal model with a high prevalence of hyperthyroidism as well as TSHR antibodies more closely resembling autoantibodies in Graves’ disease." @default.
• W1995494147 created "2016-06-24" @default.
• W1995494147 creator A5012193028 @default.
• W1995494147 creator A5018820715 @default.
• W1995494147 creator A5022600211 @default.
• W1995494147 creator A5031642047 @default.
• W1995494147 creator A5055826150 @default.
• W1995494147 creator A5065352274 @default.
• W1995494147 creator A5085029122 @default.
• W1995494147 date "2004-01-01" @default.
• W1995494147 modified "2023-10-02" @default.
• W1995494147 title "Low-Dose Immunization with Adenovirus Expressing the Thyroid-Stimulating Hormone Receptor A-Subunit Deviates the Antibody Response toward That of Autoantibodies in Human Graves’ Disease" @default.
• W1995494147 cites W1496082852 @default.
• W1995494147 cites W1937004251 @default.
• W1995494147 cites W1965540183 @default.
• W1995494147 cites W1970072991 @default.
• W1995494147 cites W1977149169 @default.
• W1995494147 cites W1981234653 @default.
• W1995494147 cites W1998556271 @default.
• W1995494147 cites W2027591735 @default.
• W1995494147 cites W2043212719 @default.
• W1995494147 cites W2075154147 @default.
• W1995494147 cites W2076466229 @default.
• W1995494147 cites W2087445302 @default.
• W1995494147 cites W2098264302 @default.
• W1995494147 cites W2104065122 @default.
• W1995494147 cites W2112396132 @default.
• W1995494147 cites W2115348768 @default.
• W1995494147 cites W2126036581 @default.
• W1995494147 cites W2133547068 @default.
• W1995494147 cites W2136309539 @default.
• W1995494147 cites W2164718616 @default.
• W1995494147 cites W2168198998 @default.
• W1995494147 cites W4248519364 @default.
• W1995494147 cites W4249432920 @default.
• W1995494147 doi "https://doi.org/10.1210/en.2003-1134" @default.
• W1995494147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14576177" @default.
• W1995494147 hasPublicationYear "2004" @default.
• W1995494147 type Work @default.
• W1995494147 sameAs 1995494147 @default.
• W1995494147 citedByCount "56" @default.
• W1995494147 countsByYear W19954941472012 @default.
• W1995494147 countsByYear W19954941472013 @default.
• W1995494147 countsByYear W19954941472014 @default.
• W1995494147 countsByYear W19954941472015 @default.
• W1995494147 countsByYear W19954941472016 @default.
• W1995494147 countsByYear W19954941472017 @default.
• W1995494147 countsByYear W19954941472018 @default.
• W1995494147 countsByYear W19954941472019 @default.
• W1995494147 countsByYear W19954941472020 @default.
• W1995494147 countsByYear W19954941472022 @default.
• W1995494147 countsByYear W19954941472023 @default.
• W1995494147 crossrefType "journal-article" @default.
• W1995494147 hasAuthorship W1995494147A5012193028 @default.
• W1995494147 hasAuthorship W1995494147A5018820715 @default.
• W1995494147 hasAuthorship W1995494147A5022600211 @default.
• W1995494147 hasAuthorship W1995494147A5031642047 @default.
• W1995494147 hasAuthorship W1995494147A5055826150 @default.
• W1995494147 hasAuthorship W1995494147A5065352274 @default.
• W1995494147 hasAuthorship W1995494147A5085029122 @default.
• W1995494147 hasBestOaLocation W19954941471 @default.
• W1995494147 hasConcept C126322002 @default.
• W1995494147 hasConcept C134018914 @default.
• W1995494147 hasConcept C159654299 @default.
• W1995494147 hasConcept C163764329 @default.
• W1995494147 hasConcept C170493617 @default.
• W1995494147 hasConcept C203014093 @default.
• W1995494147 hasConcept C2776652619 @default.
• W1995494147 hasConcept C2777608072 @default.
• W1995494147 hasConcept C2780801004 @default.
• W1995494147 hasConcept C45121317 @default.
• W1995494147 hasConcept C526584372 @default.
• W1995494147 hasConcept C71924100 @default.
• W1995494147 hasConcept C8891405 @default.
• W1995494147 hasConceptScore W1995494147C126322002 @default.
• W1995494147 hasConceptScore W1995494147C134018914 @default.
• W1995494147 hasConceptScore W1995494147C159654299 @default.
• W1995494147 hasConceptScore W1995494147C163764329 @default.
• W1995494147 hasConceptScore W1995494147C170493617 @default.
• W1995494147 hasConceptScore W1995494147C203014093 @default.
• W1995494147 hasConceptScore W1995494147C2776652619 @default.
• W1995494147 hasConceptScore W1995494147C2777608072 @default.
• W1995494147 hasConceptScore W1995494147C2780801004 @default.
• W1995494147 hasConceptScore W1995494147C45121317 @default.
• W1995494147 hasConceptScore W1995494147C526584372 @default.
• W1995494147 hasConceptScore W1995494147C71924100 @default.
• W1995494147 hasConceptScore W1995494147C8891405 @default.
• W1995494147 hasIssue "1" @default.
• W1995494147 hasLocation W19954941471 @default.
• W1995494147 hasLocation W19954941472 @default.
• W1995494147 hasOpenAccess W1995494147 @default.
• W1995494147 hasPrimaryLocation W19954941471 @default.
• W1995494147 hasRelatedWork W1963936214 @default.
• W1995494147 hasRelatedWork W1981968121 @default.
• W1995494147 hasRelatedWork W1994889999 @default.
• W1995494147 hasRelatedWork W2011960454 @default.
• W1995494147 hasRelatedWork W2060603500 @default.
• W1995494147 hasRelatedWork W2063619316 @default.

• next