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• W1995499488 abstract "Summary Objective TSH suppression therapy in patients with differentiated thyroid cancer ( DTC ) has been associated with adverse effects on areal bone mineral density (a BMD ) only in postmenopausal women. The purpose of study was to examine the effect of TSH suppression therapy on skeletal integrity using peripheral quantitative computed tomography (p QCT ) at the radius and tibia in pre‐ and postmenopausal women with DTC and controls. Study design and patients Subjects included 80 women with DTC (40 pre‐ and 40 postmenopausal ) and 89 (29 and 60, respectively) controls. p QCT was performed at the radius and tibia, Dual‐energy X‐ray absorptiometry ( DXA ) at the hip and lumbar spine, while samples were taken for calciotropic hormones and bone markers. Results No differences were observed concerning a BMD by DXA . In premenopausal women, there were no significant differences concerning v BMD , while cortical thickness was higher at the radius in patients with DTC ( P < 0·01) compared with controls. In postmenopausal women with DTC trabecular bone mineral content ( BMC ), area and v BMD were lower at the radius (all P < 0·05), while at the tibia trabecular BMC and v BMD were lower at the mixed transition zone (14% from the distal end, P < 0·05) compared with controls. Cortical thickness was lower at the radius ( P < 0·01) in postmenopausal patients compared with controls. Serum CTX was higher in postmenopausal women with DCT ( P < 0·01), while in premenopausal patients, parathyroid hormone (PTH) was lower ( P = 0·01) compared with controls. Conclusions TSH suppression therapy is associated with higher bone resorption only in postmenopausal women; this adversely affects trabecular and cortical bone properties especially at nonweight‐bearing sites such as the radius." @default.
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• W1995499488 date "2014-08-14" @default.
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• W1995499488 title "Volumetric bone mineral density and bone geometry assessed by peripheral quantitative computed tomography in women with differentiated thyroid cancer under TSH suppression" @default.
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• W1995499488 doi "https://doi.org/10.1111/cen.12560" @default.
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