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• W1995500511 abstract "Restricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Gaul Gisela and Lubbert Herman 1992Cortical astrocytes activated by basic fibroblast growth factor secrete molecules that stimulate differentiation of mesencephalic dopaminergic neuronsProc. R. Soc. Lond. B.24957–63http://doi.org/10.1098/rspb.1992.0083SectionRestricted accessArticleCortical astrocytes activated by basic fibroblast growth factor secrete molecules that stimulate differentiation of mesencephalic dopaminergic neurons Gisela Gaul Google Scholar Find this author on PubMed Search for more papers by this author and Herman Lubbert Google Scholar Find this author on PubMed Search for more papers by this author Gisela Gaul Google Scholar Find this author on PubMed Search for more papers by this author and Herman Lubbert Google Scholar Find this author on PubMed Search for more papers by this author Published:22 July 1992https://doi.org/10.1098/rspb.1992.0083AbstractIn reactive gliosis, astrocytes undergo morphological and biochemical changes which can be mimicked in vitro by treatment with bFGF (basic fibroblast growth factor) or cAMP. To investigate the influence of activated cortical astrocytes on central nervous system (CNSD) neurons, we studied the effect of the supernatant from bFGF-treated astrocytes on the development of dopaminergic neurons from rat mesencephalon. Conditioned medium of untreated astrocytes stimulated dopamine uptake of mesencephalic cultures. After activation of astrocytes with bFGF this effect was greatly enhanced. It was significantly more potent than stimulating effects of other neurotrophic factors. The supernatant of these astrocytes increased the biochemical differentiation but not the survival of dopaminergic neurons in our cell culture system. Trypsin digestion and gel chromatography revealed that the activity was due to one or several proteins with molecular mass above 5 kDa. We excluded the participation of several factors known to be produced by astrocytes or that are neurotrophic for substantia nigra cultures. In particular, we provide evidence that bFGF, BDNF, NT-3, II-1, Il-6, S I00β and α2-macroglobulin were not involved in the effect of the conditioned medium. In vitro stimulation of astrocytes therefore triggers the expression of currently uncharacterized factors which influence the biochemical differentiation of mesencephalic dopaminergic neurons, the cells that degenerate in Parkinson’s disease.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. Previous ArticleNext Article VIEW FULL TEXT DOWNLOAD PDF FiguresRelatedReferencesDetailsCited by Katiyar K, Winter C, Struzyna L, Harris J and Cullen D (2016) Mechanical elongation of astrocyte processes to create living scaffolds for nervous system regeneration, Journal of Tissue Engineering and Regenerative Medicine, 10.1002/term.2168, 11:10, (2737-2751), Online publication date: 1-Oct-2017. Sleeman I, Boshoff E and Duty S (2012) Fibroblast growth factor-20 protects against dopamine neuron loss in vitro and provides functional protection in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease, Neuropharmacology, 10.1016/j.neuropharm.2012.07.029, 63:7, (1268-1277), Online publication date: 1-Dec-2012. 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Fischer-Colbrie R, Kirchmair R, Schobert A, Olenik C, Meyer D and Winkler H (1993) Secretogranin II Is Synthesized and Secreted in Astrocyte Cultures, Journal of Neurochemistry, 10.1111/j.1471-4159.1993.tb03520.x, 60:6, (2312-2314), Online publication date: 1-Jun-1993. Maelicke A (2010) GDNF und Parkinsonismus, Nachrichten aus Chemie, Technik und Laboratorium, 10.1002/nadc.19930410713, 41:7-8, (824-825), Online publication date: 1-Jul-1993. This Issue22 July 1992Volume 249Issue 1324 Article InformationDOI:https://doi.org/10.1098/rspb.1992.0083PubMed:1279704Published by:Royal SocietyPrint ISSN:0962-8452Online ISSN:1471-2954History: Manuscript received01/04/1992Manuscript accepted27/04/1992Published online01/01/1997Published in print22/07/1992 License:Scanned images copyright © 2017, Royal Society Citations and impact Large datasets are available through Proceedings B's partnership with Dryad" @default.
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