FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995503886> ?p ?o ?g. }

• W1995503886 endingPage "80" @default.
• W1995503886 startingPage "76" @default.
• W1995503886 abstract "Recent studies have demonstrated that Rho-kinase has been proposed to play an important role in the pathogenesis of heart ischemia/reperfusion (I/R) injury. However, the mechanism of Rho-kinase mediated cardiomyocyte apoptosis in I/R is still not thoroughly understood. Studies were performed with female Wistar rats. Ischemia followed by reperfusion caused a significant increase in Rho-kinase, c-Jun NH2-terminal kinase (JNK) and apoptosis-inducing factor (AIF) activity. Administration of fasudil, an inhibitor of Rho-kinase, decreased myocardial infarction size from 59.89 ± 3.83% to 38.62 ± 2.66% (P < 0.05) and cell apoptosis from 32.78 ± 5.1% to 17.05 ± 4.2% (P < 0.05). Western blot analysis showed that administration of fasudil reduced the activation of JNK and attenuated mitochondrial-nuclear translocation of AIF. Additionally, administration of SP600125, an inhibitor of JNK, attenuated mitochondrial-nuclear translocation of AIF. The inhibition of Rho-kinase reduced cell apoptosis in I/R in vivo via suppression of JNK-mediated AIF translocation." @default.
• W1995503886 created "2016-06-24" @default.
• W1995503886 creator A5023874610 @default.
• W1995503886 creator A5032012066 @default.
• W1995503886 creator A5045703368 @default.
• W1995503886 creator A5049408398 @default.
• W1995503886 creator A5067341731 @default.
• W1995503886 creator A5086712277 @default.
• W1995503886 date "2009-03-01" @default.
• W1995503886 modified "2023-09-26" @default.
• W1995503886 title "Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation" @default.
• W1995503886 cites W1530078623 @default.
• W1995503886 cites W1966687236 @default.
• W1995503886 cites W1971284289 @default.
• W1995503886 cites W1979720860 @default.
• W1995503886 cites W1990253313 @default.
• W1995503886 cites W2006473647 @default.
• W1995503886 cites W2011906296 @default.
• W1995503886 cites W2012658767 @default.
• W1995503886 cites W2020993672 @default.
• W1995503886 cites W2022062980 @default.
• W1995503886 cites W2028721412 @default.
• W1995503886 cites W2033774856 @default.
• W1995503886 cites W2055988887 @default.
• W1995503886 cites W2069564454 @default.
• W1995503886 cites W2072180708 @default.
• W1995503886 cites W2086144679 @default.
• W1995503886 cites W2097029399 @default.
• W1995503886 cites W2114845119 @default.
• W1995503886 cites W2124320612 @default.
• W1995503886 cites W2142930120 @default.
• W1995503886 doi "https://doi.org/10.1016/j.cca.2008.11.016" @default.
• W1995503886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19061880" @default.
• W1995503886 hasPublicationYear "2009" @default.
• W1995503886 type Work @default.
• W1995503886 sameAs 1995503886 @default.
• W1995503886 citedByCount "44" @default.
• W1995503886 countsByYear W19955038862012 @default.
• W1995503886 countsByYear W19955038862013 @default.
• W1995503886 countsByYear W19955038862014 @default.
• W1995503886 countsByYear W19955038862015 @default.
• W1995503886 countsByYear W19955038862016 @default.
• W1995503886 countsByYear W19955038862017 @default.
• W1995503886 countsByYear W19955038862018 @default.
• W1995503886 countsByYear W19955038862019 @default.
• W1995503886 countsByYear W19955038862020 @default.
• W1995503886 countsByYear W19955038862021 @default.
• W1995503886 countsByYear W19955038862023 @default.
• W1995503886 crossrefType "journal-article" @default.
• W1995503886 hasAuthorship W1995503886A5023874610 @default.
• W1995503886 hasAuthorship W1995503886A5032012066 @default.
• W1995503886 hasAuthorship W1995503886A5045703368 @default.
• W1995503886 hasAuthorship W1995503886A5049408398 @default.
• W1995503886 hasAuthorship W1995503886A5067341731 @default.
• W1995503886 hasAuthorship W1995503886A5086712277 @default.
• W1995503886 hasConcept C104317684 @default.
• W1995503886 hasConcept C138626823 @default.
• W1995503886 hasConcept C153911025 @default.
• W1995503886 hasConcept C172043667 @default.
• W1995503886 hasConcept C184235292 @default.
• W1995503886 hasConcept C185592680 @default.
• W1995503886 hasConcept C190283241 @default.
• W1995503886 hasConcept C201800478 @default.
• W1995503886 hasConcept C2776048814 @default.
• W1995503886 hasConcept C31573885 @default.
• W1995503886 hasConcept C55493867 @default.
• W1995503886 hasConcept C71924100 @default.
• W1995503886 hasConcept C86803240 @default.
• W1995503886 hasConcept C95444343 @default.
• W1995503886 hasConcept C98274493 @default.
• W1995503886 hasConcept C98424977 @default.
• W1995503886 hasConceptScore W1995503886C104317684 @default.
• W1995503886 hasConceptScore W1995503886C138626823 @default.
• W1995503886 hasConceptScore W1995503886C153911025 @default.
• W1995503886 hasConceptScore W1995503886C172043667 @default.
• W1995503886 hasConceptScore W1995503886C184235292 @default.
• W1995503886 hasConceptScore W1995503886C185592680 @default.
• W1995503886 hasConceptScore W1995503886C190283241 @default.
• W1995503886 hasConceptScore W1995503886C201800478 @default.
• W1995503886 hasConceptScore W1995503886C2776048814 @default.
• W1995503886 hasConceptScore W1995503886C31573885 @default.
• W1995503886 hasConceptScore W1995503886C55493867 @default.
• W1995503886 hasConceptScore W1995503886C71924100 @default.
• W1995503886 hasConceptScore W1995503886C86803240 @default.
• W1995503886 hasConceptScore W1995503886C95444343 @default.
• W1995503886 hasConceptScore W1995503886C98274493 @default.
• W1995503886 hasConceptScore W1995503886C98424977 @default.
• W1995503886 hasIssue "1-2" @default.
• W1995503886 hasLocation W19955038861 @default.
• W1995503886 hasLocation W19955038862 @default.
• W1995503886 hasOpenAccess W1995503886 @default.
• W1995503886 hasPrimaryLocation W19955038861 @default.
• W1995503886 hasRelatedWork W1992325479 @default.
• W1995503886 hasRelatedWork W1995503886 @default.
• W1995503886 hasRelatedWork W2075370532 @default.
• W1995503886 hasRelatedWork W2159381123 @default.
• W1995503886 hasRelatedWork W2748952813 @default.
• W1995503886 hasRelatedWork W2899084033 @default.

• next