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- W1995510500 abstract "Sonicated specimens of freshly ejaculated sperm from two groups of husbands (n = 6, age 32-38 years; n = 7, age 27-38 years) of infertile couples in the range of sperm concentration between 237.5 and 568.5; 131.1 and 256.7 millions per ejaculate were separately incubated with [7n-3H]pregnenolone and [1,2,6,7(-3)H]dehydroepiandrosterone. Using the reverse-isotope dilution technique [3H]dehydroepiandrosterone and [3H]testosterone formed from the respective substrates were isolated and characterized, yielding 1.2 x 10(-2) to 4.6 x 10(-20/0) and 7.1 x 10(-2) to 2.5 x 10(-10/0)/ Such metabolites were not evident in the controls. These results provide evidence for metabolic transformation of pregnenolone to testosterone via the delta 5-3 beta-hydroxy route." @default.
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- W1995510500 date "1997-01-01" @default.
- W1995510500 modified "2023-10-16" @default.
- W1995510500 title "Characterization of a Δ5-3β-Hydroxy Pathway of Testosterone Synthesis in the Human Spermatozoa" @default.
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- W1995510500 doi "https://doi.org/10.3109/01485019708988534" @default.
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