FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995514232> ?p ?o ?g. }

• W1995514232 endingPage "29" @default.
• W1995514232 startingPage "21" @default.
• W1995514232 abstract "The tetrameric Lac repressor can bind simultaneously to two lac operators on the same DNA molecule, thereby including the formation of a DNA loop. We investigated the phasing dependence of DNA loop formation between lac operator O1 and an auxiliary ideal lac operator (O(id)) on the bacterial chromosome, with inter-operator distances varying from 57.5 to 1493.5 bp. Repression of a CAP-independent lac UV5 promoter by O1 at its natural position increased up to 50-fold in the presence of an optimally positioned auxiliary O(id)). Repression values alternated between local maxima and minima with a periodicity of 11.0 to 11.3 bp, suggesting that the chromosomal helical repeat is in this range in vivo. Repression increased significantly with decreasing inter-operator DNA length, indicating that the local Lac repressor concentration at O1 is crucial for tight repression. Maximal repression, attributed to stable DNA loop formation, was obtained at an operator spacing of 70.5 bp. Other repression maxima occurred at operator distances of 92.5 and 115.5 bp, corresponding to natural operator spacings in the lac and in the gal operon, respectively. Substitution of the auxiliary O(id) with the weaker binding lac operator O3 lowered repression efficiency, presumably due to the reduced local concentration of Lac repressor." @default.
• W1995514232 created "2016-06-24" @default.
• W1995514232 creator A5000339271 @default.
• W1995514232 creator A5028013403 @default.
• W1995514232 creator A5060850966 @default.
• W1995514232 date "1996-03-01" @default.
• W1995514232 modified "2023-10-18" @default.
• W1995514232 title "Repression oflacPromoter as a Function of Distance, Phase and Quality of an AuxiliarylacOperator" @default.
• W1995514232 cites W133821640 @default.
• W1995514232 cites W1466300122 @default.
• W1995514232 cites W1515974446 @default.
• W1995514232 cites W1515986743 @default.
• W1995514232 cites W1544991224 @default.
• W1995514232 cites W1546783991 @default.
• W1995514232 cites W1577909016 @default.
• W1995514232 cites W1580777924 @default.
• W1995514232 cites W1591758727 @default.
• W1995514232 cites W1617454400 @default.
• W1995514232 cites W1823544094 @default.
• W1995514232 cites W187856650 @default.
• W1995514232 cites W1940781171 @default.
• W1995514232 cites W1966443347 @default.
• W1995514232 cites W1970601901 @default.
• W1995514232 cites W1979138386 @default.
• W1995514232 cites W1980946235 @default.
• W1995514232 cites W1985039493 @default.
• W1995514232 cites W1986712100 @default.
• W1995514232 cites W1987063642 @default.
• W1995514232 cites W1993724696 @default.
• W1995514232 cites W1993748356 @default.
• W1995514232 cites W1996671825 @default.
• W1995514232 cites W2017036937 @default.
• W1995514232 cites W2024214216 @default.
• W1995514232 cites W2033143360 @default.
• W1995514232 cites W2052334453 @default.
• W1995514232 cites W2058215672 @default.
• W1995514232 cites W2058940094 @default.
• W1995514232 cites W2060417297 @default.
• W1995514232 cites W2061945127 @default.
• W1995514232 cites W2063173678 @default.
• W1995514232 cites W2066267034 @default.
• W1995514232 cites W2067133629 @default.
• W1995514232 cites W2067165394 @default.
• W1995514232 cites W2074621528 @default.
• W1995514232 cites W2081036035 @default.
• W1995514232 cites W2084916160 @default.
• W1995514232 cites W2090295342 @default.
• W1995514232 cites W2092388854 @default.
• W1995514232 cites W2138270253 @default.
• W1995514232 cites W2141778672 @default.
• W1995514232 cites W2148922163 @default.
• W1995514232 cites W2152842787 @default.
• W1995514232 cites W2334515620 @default.
• W1995514232 cites W257633441 @default.
• W1995514232 cites W33216127 @default.
• W1995514232 cites W456191 @default.
• W1995514232 cites W58950924 @default.
• W1995514232 doi "https://doi.org/10.1006/jmbi.1996.0143" @default.
• W1995514232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8632456" @default.
• W1995514232 hasPublicationYear "1996" @default.
• W1995514232 type Work @default.
• W1995514232 sameAs 1995514232 @default.
• W1995514232 citedByCount "242" @default.
• W1995514232 countsByYear W19955142322012 @default.
• W1995514232 countsByYear W19955142322013 @default.
• W1995514232 countsByYear W19955142322014 @default.
• W1995514232 countsByYear W19955142322015 @default.
• W1995514232 countsByYear W19955142322016 @default.
• W1995514232 countsByYear W19955142322017 @default.
• W1995514232 countsByYear W19955142322018 @default.
• W1995514232 countsByYear W19955142322019 @default.
• W1995514232 countsByYear W19955142322020 @default.
• W1995514232 countsByYear W19955142322021 @default.
• W1995514232 countsByYear W19955142322022 @default.
• W1995514232 countsByYear W19955142322023 @default.
• W1995514232 crossrefType "journal-article" @default.
• W1995514232 hasAuthorship W1995514232A5000339271 @default.
• W1995514232 hasAuthorship W1995514232A5028013403 @default.
• W1995514232 hasAuthorship W1995514232A5060850966 @default.
• W1995514232 hasConcept C104317684 @default.
• W1995514232 hasConcept C113629113 @default.
• W1995514232 hasConcept C121332964 @default.
• W1995514232 hasConcept C150194340 @default.
• W1995514232 hasConcept C158448853 @default.
• W1995514232 hasConcept C17020691 @default.
• W1995514232 hasConcept C170344550 @default.
• W1995514232 hasConcept C185592680 @default.
• W1995514232 hasConcept C186310378 @default.
• W1995514232 hasConcept C203075996 @default.
• W1995514232 hasConcept C22744801 @default.
• W1995514232 hasConcept C54355233 @default.
• W1995514232 hasConcept C547475151 @default.
• W1995514232 hasConcept C552990157 @default.
• W1995514232 hasConcept C71240020 @default.
• W1995514232 hasConcept C86803240 @default.
• W1995514232 hasConceptScore W1995514232C104317684 @default.
• W1995514232 hasConceptScore W1995514232C113629113 @default.
• W1995514232 hasConceptScore W1995514232C121332964 @default.

• next