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- W1995533323 abstract "The electrophysiological effects of trimebutine maleate were studied on rabbit sinus node cells with the two-microelectrode voltage clamp method. Trimebutine (above 10 microM) produced a negative chronotropic effect accompanied by decreases in the maximum upstroke velocity at phase 0, slope of phase 4 depolarization and action potential amplitude. The effects on the current systems were depression of the slow inward current and a decrease in the current oscillations induced by elevating [Ca]0. It is concluded that trimebutine exerts a Ca2+ channel blocking effect on the sinus node pacemaker cells." @default.
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- W1995533323 date "1987-12-01" @default.
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- W1995533323 title "Effect of trimebutine maleate on sinus node pacemaker activity of the rabbit" @default.
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- W1995533323 doi "https://doi.org/10.1016/0014-2999(87)90385-2" @default.
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