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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995536189> ?p ?o ?g. }

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• W1995536189 abstract "A series of 1-aryl-3,4-dihydroisoquinoline inhibitors of JNK3 are described. Compounds 20 and 24 are the most potent inhibitors (pIC50 7.3 and 6.9, respectively in a radiometric filter binding assay), with 10- and 1000-fold selectivity over JNK2 and JNK1, respectively, and selectivity within the wider mitogen-activated protein kinase (MAPK) family against p38α and ERK2. X-ray crystallography of 16 reveals a highly unusual binding mode where an H-bond acceptor interaction with the hinge region is made by a chloro substituent." @default.
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• W1995536189 date "2009-04-01" @default.
• W1995536189 modified "2023-10-15" @default.
• W1995536189 title "1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3" @default.
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• W1995536189 doi "https://doi.org/10.1016/j.bmcl.2009.02.098" @default.
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