FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995542024> ?p ?o ?g. }

• W1995542024 endingPage "202" @default.
• W1995542024 startingPage "193" @default.
• W1995542024 abstract "The neurotoxic effect of the excitatory amino acid neurotransmitter glutamate was first demonstrated 20 years ago, but the recent development of potent glutamate antagonist drugs with effects against ischaemic damage in vivo and their introduction in clinical studies has made 'excitotoxicity' a major focus of current interest. Despite this, the factors influencing glutamate neurotoxicity in vivo are poorly understood, and the role of glutamate as a neurotoxin in vivo is contested. By using a microdialysis probe to deliver glutamate to the normal rat cortex, we have devised a reproducible model of peracute 'excitotoxic' damage. We have demonstrated that concentrations of over 20 mM glutamate in the perfusate kill neurons in the intact brain in less than 90 min -20 to 200 times more than that required for toxicity in mixed cell culture. The histological and ultrastructural features of the glutamate lesion are very similar to those of acute ischaemia, although their development is much more rapid after glutamate. True extracellular glutamate concentrations estimated from microdialysis studies (about 4 mM) are not far from our results. The reproducible quantifiable nature of the glutamate lesions in this model make it well suited to study the factors affecting the excitotoxic process in vivo." @default.
• W1995542024 created "2016-06-24" @default.
• W1995542024 creator A5024556357 @default.
• W1995542024 creator A5031263597 @default.
• W1995542024 creator A5047799869 @default.
• W1995542024 creator A5055886560 @default.
• W1995542024 creator A5072425669 @default.
• W1995542024 date "1998-04-01" @default.
• W1995542024 modified "2023-09-27" @default.
• W1995542024 title "Reproducible peracute glutamate-induced focal lesions of the normal rat brain using microdialysis" @default.
• W1995542024 cites W1576577565 @default.
• W1995542024 cites W1896952141 @default.
• W1995542024 cites W1976265701 @default.
• W1995542024 cites W1976754780 @default.
• W1995542024 cites W1980322487 @default.
• W1995542024 cites W2005608576 @default.
• W1995542024 cites W2006904109 @default.
• W1995542024 cites W2009788226 @default.
• W1995542024 cites W2015761960 @default.
• W1995542024 cites W2020220055 @default.
• W1995542024 cites W2029515915 @default.
• W1995542024 cites W2031702150 @default.
• W1995542024 cites W2035750459 @default.
• W1995542024 cites W2037611507 @default.
• W1995542024 cites W2042550512 @default.
• W1995542024 cites W2051395367 @default.
• W1995542024 cites W2065636160 @default.
• W1995542024 cites W2075212315 @default.
• W1995542024 cites W2087916050 @default.
• W1995542024 cites W2088283432 @default.
• W1995542024 cites W2121179906 @default.
• W1995542024 cites W2137726937 @default.
• W1995542024 cites W3002740628 @default.
• W1995542024 doi "https://doi.org/10.1016/s0967-5868(98)90037-6" @default.
• W1995542024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18639011" @default.
• W1995542024 hasPublicationYear "1998" @default.
• W1995542024 type Work @default.
• W1995542024 sameAs 1995542024 @default.
• W1995542024 citedByCount "14" @default.
• W1995542024 countsByYear W19955420242015 @default.
• W1995542024 countsByYear W19955420242016 @default.
• W1995542024 countsByYear W19955420242018 @default.
• W1995542024 countsByYear W19955420242020 @default.
• W1995542024 crossrefType "journal-article" @default.
• W1995542024 hasAuthorship W1995542024A5024556357 @default.
• W1995542024 hasAuthorship W1995542024A5031263597 @default.
• W1995542024 hasAuthorship W1995542024A5047799869 @default.
• W1995542024 hasAuthorship W1995542024A5055886560 @default.
• W1995542024 hasAuthorship W1995542024A5072425669 @default.
• W1995542024 hasConcept C126322002 @default.
• W1995542024 hasConcept C150903083 @default.
• W1995542024 hasConcept C169760540 @default.
• W1995542024 hasConcept C170493617 @default.
• W1995542024 hasConcept C207001950 @default.
• W1995542024 hasConcept C2776219046 @default.
• W1995542024 hasConcept C2779491297 @default.
• W1995542024 hasConcept C2780358027 @default.
• W1995542024 hasConcept C2781012912 @default.
• W1995542024 hasConcept C28406088 @default.
• W1995542024 hasConcept C29730261 @default.
• W1995542024 hasConcept C50156730 @default.
• W1995542024 hasConcept C529278444 @default.
• W1995542024 hasConcept C55493867 @default.
• W1995542024 hasConcept C61174792 @default.
• W1995542024 hasConcept C71924100 @default.
• W1995542024 hasConcept C86803240 @default.
• W1995542024 hasConcept C98274493 @default.
• W1995542024 hasConceptScore W1995542024C126322002 @default.
• W1995542024 hasConceptScore W1995542024C150903083 @default.
• W1995542024 hasConceptScore W1995542024C169760540 @default.
• W1995542024 hasConceptScore W1995542024C170493617 @default.
• W1995542024 hasConceptScore W1995542024C207001950 @default.
• W1995542024 hasConceptScore W1995542024C2776219046 @default.
• W1995542024 hasConceptScore W1995542024C2779491297 @default.
• W1995542024 hasConceptScore W1995542024C2780358027 @default.
• W1995542024 hasConceptScore W1995542024C2781012912 @default.
• W1995542024 hasConceptScore W1995542024C28406088 @default.
• W1995542024 hasConceptScore W1995542024C29730261 @default.
• W1995542024 hasConceptScore W1995542024C50156730 @default.
• W1995542024 hasConceptScore W1995542024C529278444 @default.
• W1995542024 hasConceptScore W1995542024C55493867 @default.
• W1995542024 hasConceptScore W1995542024C61174792 @default.
• W1995542024 hasConceptScore W1995542024C71924100 @default.
• W1995542024 hasConceptScore W1995542024C86803240 @default.
• W1995542024 hasConceptScore W1995542024C98274493 @default.
• W1995542024 hasIssue "2" @default.
• W1995542024 hasLocation W19955420241 @default.
• W1995542024 hasLocation W19955420242 @default.
• W1995542024 hasOpenAccess W1995542024 @default.
• W1995542024 hasPrimaryLocation W19955420241 @default.
• W1995542024 hasRelatedWork W1528514923 @default.
• W1995542024 hasRelatedWork W1972851188 @default.
• W1995542024 hasRelatedWork W1994371606 @default.
• W1995542024 hasRelatedWork W1995542024 @default.
• W1995542024 hasRelatedWork W2011822918 @default.
• W1995542024 hasRelatedWork W2027288915 @default.
• W1995542024 hasRelatedWork W2051395367 @default.
• W1995542024 hasRelatedWork W2527136737 @default.

• next