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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995546729> ?p ?o ?g. }

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• W1995546729 abstract "Altered degradation of extracellular matrix has been implicated in the pathogenesis of hepatic fibrosis. We studied the effect of acetaldehyde (AcCHO) on gene expression of matrix-metalloproteinase (MMP)-1 (fibroblast type- interstitial collagenase) and MMP-2 (72 kDa gelatinase-type IV collagenase) in comparison with the AcCHO effect on collagen type I and IV synthesis in cultures of fat-storing cells (FSC) isolated from normal human livers. Cultured human FSC expressed single mRNA transcripts (2.7 and 3.2 kb) specific for MMP-1 and MMP-2, respectively. AcCHO inhibited MMP-1 mRNA levels, whereas it stimulated collagen type I mRNA and protein expression. Opposite AcCHO effects were evident on MMP-2 mRNA and collagen IV synthesis, being MMP-2 up-regulated and collagen IV down-regulated. These data suggest that regulation of MMP-1 and MMP-2 genes by AcCHO may contribute to disruption of the normal basement membrane and its replacement with fibrillar collagens in the early stages of alcoholic liver fibrosis." @default.
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• W1995546729 date "1994-01-01" @default.
• W1995546729 modified "2023-09-26" @default.
• W1995546729 title "Acetaldehyde regulates the gene expression of matrix-metalloproteinase-1 and -2 in human fat-storing cells" @default.
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• W1995546729 doi "https://doi.org/10.1016/0024-3205(94)00763-2" @default.
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