FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995550123> ?p ?o ?g. }

• W1995550123 endingPage "5033" @default.
• W1995550123 startingPage "5027" @default.
• W1995550123 abstract "ABSTRACT Although the artemisinin-associated neurotoxicity identified in vitro and in animal studies has not been confirmed clinically, only one adult study has measured cerebrospinal fluid (CSF) concentrations after administration of conventional doses. Potential artemisinin neurotoxicity could be serious in children, especially those with meningitis and, consequently, a compromised blood-brain barrier. We measured CSF/plasma artemether and dihydroartemisinin (DHA) concentrations in 32 Papua New Guinean children with a mean age of 39 months with suspected or proven severe falciparum malaria who underwent a single lumbar puncture after intramuscular artemether administration. CSF artemether concentrations were 0 to 43.5 μg/liter and CSF concentration/plasma concentration ratios were 0 to 38.1%. DHA was measurable in CSF in only two children. The seven children with meningeal inflammation (CSF white cell count > 20/mm 3 ) had higher CSF artemether concentration/plasma artemether concentration ratios than those without (median, 6.7% [interquartile ratio, 2.5 to 27.8%]% versus 0.0% [interquartile ratio, 0.0 to 2.5%]; P = 0.002). Meningeal inflammation was associated with a 4.6-fold increase in the CSF artemether concentration/plasma artemether concentration ratio in a population pharmacokinetic model. These data suggest that pharmacovigilance should be heightened when intramuscular artemether is given to severely ill children with evidence of meningeal inflammation." @default.
• W1995550123 created "2016-06-24" @default.
• W1995550123 creator A5004820565 @default.
• W1995550123 creator A5011734446 @default.
• W1995550123 creator A5020890152 @default.
• W1995550123 creator A5031856201 @default.
• W1995550123 creator A5040081397 @default.
• W1995550123 creator A5043426673 @default.
• W1995550123 creator A5060701254 @default.
• W1995550123 creator A5069420520 @default.
• W1995550123 creator A5082061848 @default.
• W1995550123 creator A5084635606 @default.
• W1995550123 date "2011-08-22" @default.
• W1995550123 modified "2023-09-23" @default.
• W1995550123 title "Meningeal Inflammation Increases Artemether Concentrations in Cerebrospinal Fluid in Papua New Guinean Children Treated with Intramuscular Artemether" @default.
• W1995550123 cites W1673362020 @default.
• W1995550123 cites W1951642591 @default.
• W1995550123 cites W1963764812 @default.
• W1995550123 cites W1967541552 @default.
• W1995550123 cites W1969790923 @default.
• W1995550123 cites W1975267889 @default.
• W1995550123 cites W1977775413 @default.
• W1995550123 cites W1981972560 @default.
• W1995550123 cites W1991018224 @default.
• W1995550123 cites W1996976640 @default.
• W1995550123 cites W1997380789 @default.
• W1995550123 cites W2001781050 @default.
• W1995550123 cites W2014392076 @default.
• W1995550123 cites W2016183203 @default.
• W1995550123 cites W2023488655 @default.
• W1995550123 cites W2027269904 @default.
• W1995550123 cites W2033923082 @default.
• W1995550123 cites W2039192863 @default.
• W1995550123 cites W2044757666 @default.
• W1995550123 cites W2046415190 @default.
• W1995550123 cites W2047632146 @default.
• W1995550123 cites W2050226999 @default.
• W1995550123 cites W2061083280 @default.
• W1995550123 cites W2068010867 @default.
• W1995550123 cites W2079864056 @default.
• W1995550123 cites W2080816163 @default.
• W1995550123 cites W2085034480 @default.
• W1995550123 cites W2090613637 @default.
• W1995550123 cites W2103508330 @default.
• W1995550123 cites W2108347546 @default.
• W1995550123 cites W2110383454 @default.
• W1995550123 cites W2112251156 @default.
• W1995550123 cites W2116270585 @default.
• W1995550123 cites W2120416054 @default.
• W1995550123 cites W2125898806 @default.
• W1995550123 cites W2131986609 @default.
• W1995550123 cites W2139084523 @default.
• W1995550123 cites W2140603169 @default.
• W1995550123 cites W2141823493 @default.
• W1995550123 cites W2161311583 @default.
• W1995550123 cites W2162661614 @default.
• W1995550123 cites W2162779994 @default.
• W1995550123 cites W2169918301 @default.
• W1995550123 cites W2188520041 @default.
• W1995550123 cites W2213792670 @default.
• W1995550123 cites W2313139941 @default.
• W1995550123 cites W2320022633 @default.
• W1995550123 cites W2983049110 @default.
• W1995550123 cites W4211010162 @default.
• W1995550123 doi "https://doi.org/10.1128/aac.00375-11" @default.
• W1995550123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3195017" @default.
• W1995550123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21859936" @default.
• W1995550123 hasPublicationYear "2011" @default.
• W1995550123 type Work @default.
• W1995550123 sameAs 1995550123 @default.
• W1995550123 citedByCount "14" @default.
• W1995550123 countsByYear W19955501232012 @default.
• W1995550123 countsByYear W19955501232013 @default.
• W1995550123 countsByYear W19955501232014 @default.
• W1995550123 countsByYear W19955501232015 @default.
• W1995550123 countsByYear W19955501232016 @default.
• W1995550123 countsByYear W19955501232018 @default.
• W1995550123 countsByYear W19955501232019 @default.
• W1995550123 crossrefType "journal-article" @default.
• W1995550123 hasAuthorship W1995550123A5004820565 @default.
• W1995550123 hasAuthorship W1995550123A5011734446 @default.
• W1995550123 hasAuthorship W1995550123A5020890152 @default.
• W1995550123 hasAuthorship W1995550123A5031856201 @default.
• W1995550123 hasAuthorship W1995550123A5040081397 @default.
• W1995550123 hasAuthorship W1995550123A5043426673 @default.
• W1995550123 hasAuthorship W1995550123A5060701254 @default.
• W1995550123 hasAuthorship W1995550123A5069420520 @default.
• W1995550123 hasAuthorship W1995550123A5082061848 @default.
• W1995550123 hasAuthorship W1995550123A5084635606 @default.
• W1995550123 hasBestOaLocation W19955501231 @default.
• W1995550123 hasConcept C112705442 @default.
• W1995550123 hasConcept C119060515 @default.
• W1995550123 hasConcept C126322002 @default.
• W1995550123 hasConcept C203014093 @default.
• W1995550123 hasConcept C2776120307 @default.
• W1995550123 hasConcept C2778048844 @default.
• W1995550123 hasConcept C2778118209 @default.
• W1995550123 hasConcept C2778371730 @default.

• next