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- W1995557708 abstract "The nonlinear least-squares model for the calculation of the stability constants (Kst) of drug:cyclodextrin complexes was used in kinetic studies. Complexation of riboflavin (R) with hydroxypropyl-β-cyclodextrin (HP:β-CD) was monitored kinetically by measuring the rate of photodegradation of R exposed to ultraviolet light in the presence of increasing concentrations of HP:β-CD. Formation of inclusion complex was confirmed in aqueous solution by proton nuclear magnetic resonance spectroscopy (1H-NMR). The experimental Kst value (3321 M−1), derived from the kinetic studies, appeared to fit well to a 1:1 drug: cyclodextrin molar ratio according to the nonlinear mathematical model. The model is particularly suitable for the study of cyclodextrin as a stabilizing system for compounds that are sensitive to light, oxygen, temperature or the media which contain them." @default.
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- W1995557708 date "1996-11-01" @default.
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- W1995557708 title "Use of a nonlinear least-squares model for the kinetic determination of the stability constant of cyclodextrin inclusion complexes" @default.
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- W1995557708 doi "https://doi.org/10.1016/s0378-5173(96)04759-x" @default.
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