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- W1995575432 abstract "A 54-year-old woman presented with night sweats, lethargy and cervical lymphadenopathy. She had also noticed yellowish discoloration of her finger-nails. A computed tomography (CT) scan showed widespread lymphadenopathy in the abdomen and pelvis (maximum node diameter 5 cm). Histology of a cervical lymph node demonstrated features of follicular lymphoma (grade IIIa). An early clinical response was seen following commencement of chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone; R-CHOP) including resolution of the nail discoloration, which had reverted to normal by cycle 6. A subsequent CT scan confirmed complete remission. Yellow nail syndrome is a rare entity of unknown aetiology. The classic triad consisted of lymphoedaema, slow-growing yellow nails and pleural effusions. Yellowish discoloration of nails has also been reported in association with immune disorders, immunodeficiency states, infections (e.g. tuberculosis and human immunodeficiency virus infection) and malignant diseases. The latter include carcinoma of the breast, larynx, lung, endometrium and gall bladder. We are aware of only two cases described in association with non-Hodgkin lymphoma. In one case, the changes persisted despite remission of the lymphoma. In the other case, the nail discoloration resolved with complete remission of the disease, but recurred when the disease relapsed 4 months later. The association of yellow nails and lymphoma is rare but seems to reflect active underlying disease." @default.
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- W1995575432 date "2006-10-25" @default.
- W1995575432 modified "2023-10-16" @default.
- W1995575432 title "Yellow nails in non-Hodgkin lymphoma" @default.
- W1995575432 doi "https://doi.org/10.1111/j.1365-2141.2006.06347.x" @default.
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