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- W1995596056 abstract "Battlefield hemorrhage remains the primary cause of death in potentially survivable combat injuries with noncompressible hemorrhage. Fibrin dressings have great potential for reducing mortality, however are limited by cost, availability, and disease transmission. The dressings comprising a soluble dextran dressing with lyophilized salmon thrombin and fibrinogen (STF) were tested against Combat Gauze (CG) as a control in a standard swine femoral artery hemorrhage model. Ten female swine were used in each arm of the study. The survival, blood loss, and time to hemostasis were similar between the two dressings. Two of the CG treated animals that survived exsanguinated during the simulated walking maneuver. Three CG-treated animals formed a clot within the wound, but the clot did not adhere to the femoral artery injury. All ten of the STF treated animals formed a clot in the wound that adhered and sealed the arterial injury site, even in three animals that did not survive. None of the STF-treated animals bled following the simulated walking maneuver. Three of five STF-treated animals reestablished blood flow distal to the injury as demonstrated by angiography. The authors concluded that the STF dressing is as efficacious as CG in treating hemorrhage in this model of a lethal injury. Further, the STF dressing formed a fibrin sealant over the injury, whereas CG achieved hemostasis by occlusive compression of the artery. The sealant property of the STF dressing allowed reestablishment of antegrade blood flow into the distal limb, demonstrating that this dressing has the potential of limb salvage in addition to control of life-threatening hemorrhage.Contributed by:Col Man Mohan HarjaiSenior Advisor in Surgery and Paediatric Surgery, Command Hospital (SC), Pune 411040, India" @default.
- W1995596056 created "2016-06-24" @default.
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- W1995596056 date "2012-07-01" @default.
- W1995596056 modified "2023-10-01" @default.
- W1995596056 title "A salmon thrombin-fibrinogen dressing controls hemorrhage in a Swine model compared to standard kaolin-coated gauze" @default.
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- W1995596056 doi "https://doi.org/10.1016/j.mjafi.2012.06.002" @default.
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