Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995596707> ?p ?o ?g. }
- W1995596707 endingPage "723" @default.
- W1995596707 startingPage "714" @default.
- W1995596707 abstract "Xin and nebulette are striated muscle-specific actin-binding proteins that both contain multiple actin-binding repeats. The nature of these repeats is different: nebulette has nebulin-like repeats, while Xin contains its own unique repeats. However, the suggestion was made from biochemical data that the Xin-repeats may bind to multiple sites on the actin molecule as was found for nebulin. We have used electron microscopy and the iterative helical real space reconstruction to visualize complexes of F-actin with Xin fragments containing either three or six Xin-repeats, and with the CN5-nebulette fragment, containing five nebulin-like repeats. Our results indicate that Xin and nebulette fragments bind to F-actin in a similar manner and in two distinct modes: in one mode actin subdomain 1 is bound, while in the second mode the binding bridges between a different site on actin subdomains 1/2 of one protomer and subdomains 3/4 of an adjacent actin protomer. Taken together with published data about nebulin, tropomyosin and ADF/cofilin, our results suggest that the ability to bind in multiple modes to the actin protomer is a general property of many actin-binding proteins." @default.
- W1995596707 created "2016-06-24" @default.
- W1995596707 creator A5014879094 @default.
- W1995596707 creator A5054885812 @default.
- W1995596707 creator A5061780801 @default.
- W1995596707 creator A5061953486 @default.
- W1995596707 creator A5063231310 @default.
- W1995596707 creator A5083618930 @default.
- W1995596707 creator A5091500513 @default.
- W1995596707 date "2006-02-01" @default.
- W1995596707 modified "2023-10-16" @default.
- W1995596707 title "Xin-repeats and Nebulin-like Repeats Bind to F-actin in a Similar Manner" @default.
- W1995596707 cites W1517257838 @default.
- W1995596707 cites W1587805792 @default.
- W1995596707 cites W1613064972 @default.
- W1995596707 cites W164743042 @default.
- W1995596707 cites W1840617397 @default.
- W1995596707 cites W1921408963 @default.
- W1995596707 cites W1971393829 @default.
- W1995596707 cites W1978888273 @default.
- W1995596707 cites W1990060194 @default.
- W1995596707 cites W1998906599 @default.
- W1995596707 cites W1999859427 @default.
- W1995596707 cites W2000422874 @default.
- W1995596707 cites W2003300699 @default.
- W1995596707 cites W2011498709 @default.
- W1995596707 cites W2017716708 @default.
- W1995596707 cites W2027959790 @default.
- W1995596707 cites W2035270427 @default.
- W1995596707 cites W2043316605 @default.
- W1995596707 cites W2044629144 @default.
- W1995596707 cites W2048982317 @default.
- W1995596707 cites W2051308999 @default.
- W1995596707 cites W2052261000 @default.
- W1995596707 cites W2055002273 @default.
- W1995596707 cites W2057644632 @default.
- W1995596707 cites W2058497997 @default.
- W1995596707 cites W2061679830 @default.
- W1995596707 cites W2065131378 @default.
- W1995596707 cites W2068284623 @default.
- W1995596707 cites W2074570334 @default.
- W1995596707 cites W2077970953 @default.
- W1995596707 cites W2078718920 @default.
- W1995596707 cites W2084314403 @default.
- W1995596707 cites W2090847463 @default.
- W1995596707 cites W2094603514 @default.
- W1995596707 cites W2097274012 @default.
- W1995596707 cites W2113092027 @default.
- W1995596707 cites W2120911894 @default.
- W1995596707 cites W2132629607 @default.
- W1995596707 cites W2133362538 @default.
- W1995596707 cites W2135741762 @default.
- W1995596707 cites W2136650462 @default.
- W1995596707 cites W2145345825 @default.
- W1995596707 cites W2150222625 @default.
- W1995596707 cites W2334869316 @default.
- W1995596707 doi "https://doi.org/10.1016/j.jmb.2005.11.082" @default.
- W1995596707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16384582" @default.
- W1995596707 hasPublicationYear "2006" @default.
- W1995596707 type Work @default.
- W1995596707 sameAs 1995596707 @default.
- W1995596707 citedByCount "24" @default.
- W1995596707 countsByYear W19955967072012 @default.
- W1995596707 countsByYear W19955967072013 @default.
- W1995596707 countsByYear W19955967072014 @default.
- W1995596707 countsByYear W19955967072015 @default.
- W1995596707 countsByYear W19955967072016 @default.
- W1995596707 countsByYear W19955967072018 @default.
- W1995596707 countsByYear W19955967072022 @default.
- W1995596707 crossrefType "journal-article" @default.
- W1995596707 hasAuthorship W1995596707A5014879094 @default.
- W1995596707 hasAuthorship W1995596707A5054885812 @default.
- W1995596707 hasAuthorship W1995596707A5061780801 @default.
- W1995596707 hasAuthorship W1995596707A5061953486 @default.
- W1995596707 hasAuthorship W1995596707A5063231310 @default.
- W1995596707 hasAuthorship W1995596707A5083618930 @default.
- W1995596707 hasAuthorship W1995596707A5091500513 @default.
- W1995596707 hasConcept C125705527 @default.
- W1995596707 hasConcept C130861313 @default.
- W1995596707 hasConcept C142669718 @default.
- W1995596707 hasConcept C1491633281 @default.
- W1995596707 hasConcept C185592680 @default.
- W1995596707 hasConcept C205875245 @default.
- W1995596707 hasConcept C207200792 @default.
- W1995596707 hasConcept C2776601116 @default.
- W1995596707 hasConcept C2993400109 @default.
- W1995596707 hasConcept C3620293 @default.
- W1995596707 hasConcept C55493867 @default.
- W1995596707 hasConcept C68731436 @default.
- W1995596707 hasConcept C83323008 @default.
- W1995596707 hasConcept C86803240 @default.
- W1995596707 hasConcept C90671521 @default.
- W1995596707 hasConcept C95444343 @default.
- W1995596707 hasConceptScore W1995596707C125705527 @default.
- W1995596707 hasConceptScore W1995596707C130861313 @default.
- W1995596707 hasConceptScore W1995596707C142669718 @default.
- W1995596707 hasConceptScore W1995596707C1491633281 @default.
- W1995596707 hasConceptScore W1995596707C185592680 @default.