FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995597122> ?p ?o ?g. }

• W1995597122 endingPage "140" @default.
• W1995597122 startingPage "134" @default.
• W1995597122 abstract "In a previous study, our laboratory reported that sildenafil citrate, a cyclic nucleotide phosphodiesterase type 5 inhibitor, reversed a learning impairment in rats induced by systemic inhibition of nitric oxide synthase (60 mg/kg, i.p., Nω-nitro-L-arginine methyl ester; L-NAME). To limit the peripheral effects of L-NAME and further localize the site of action of sildenafil, L-NAME (48 μg, i.c.v.) was infused bilaterally into the lateral cerebral ventricles 30 min prior to maze training. Saline or sildenafil citrate (1.5 or 3.0 mg/kg, i.p.) was administered systemically 15 min before training. Drug injections occurred 24 h after pretraining rats to avoid foot shock on a one-way active avoidance straight runway. Following drug treatment, the rats received 15 training trials on a 14-unit T-maze task that requires learning a complex sequence of turns to avoid mild foot shock. This complex maze paradigm is sensitive to aging and blockade of cholinergic, N-methyl-D-aspartate and nitric oxide signaling systems. Behavioral measures of performance included deviations from the correct pathway (errors), runtime from start to goal (latency), shock frequency and shock duration. Statistical analysis revealed that central infusion of L-NAME impaired maze performance and that sildenafil (3.0 mg/kg) significantly attenuated the impairment. These results suggest that sildenafil citrate may serve as a cognitive enhancer by modulating central nitric oxide/cGMP signal transduction following N-methyl-D-aspartate receptor activation. This pathway has been implicated in age-related cognitive decline and may be a useful target for pharmacological intervention of neurodegenerative disease." @default.
• W1995597122 created "2016-06-24" @default.
• W1995597122 creator A5013212790 @default.
• W1995597122 creator A5022251174 @default.
• W1995597122 creator A5024636973 @default.
• W1995597122 creator A5033786807 @default.
• W1995597122 creator A5037215222 @default.
• W1995597122 creator A5044264789 @default.
• W1995597122 creator A5067795179 @default.
• W1995597122 creator A5070711251 @default.
• W1995597122 creator A5083347752 @default.
• W1995597122 creator A5089492406 @default.
• W1995597122 date "2007-06-01" @default.
• W1995597122 modified "2023-10-14" @default.
• W1995597122 title "Sildenafil citrate attenuates a complex maze impairment induced by intracerebroventricular infusion of the NOS inhibitor Nω-nitro-L-arginine methyl ester" @default.
• W1995597122 cites W1490962304 @default.
• W1995597122 cites W1493112951 @default.
• W1995597122 cites W1511208409 @default.
• W1995597122 cites W1563544244 @default.
• W1995597122 cites W1902300865 @default.
• W1995597122 cites W1943597576 @default.
• W1995597122 cites W1959582949 @default.
• W1995597122 cites W1967480902 @default.
• W1995597122 cites W1969784828 @default.
• W1995597122 cites W1980676233 @default.
• W1995597122 cites W1981762797 @default.
• W1995597122 cites W1984122305 @default.
• W1995597122 cites W1984541066 @default.
• W1995597122 cites W1985900925 @default.
• W1995597122 cites W1990046751 @default.
• W1995597122 cites W1994067502 @default.
• W1995597122 cites W1997239063 @default.
• W1995597122 cites W1999740538 @default.
• W1995597122 cites W2002827758 @default.
• W1995597122 cites W2002956393 @default.
• W1995597122 cites W2005766376 @default.
• W1995597122 cites W2008037029 @default.
• W1995597122 cites W2008350078 @default.
• W1995597122 cites W2016283334 @default.
• W1995597122 cites W2026745182 @default.
• W1995597122 cites W2035584685 @default.
• W1995597122 cites W2043392738 @default.
• W1995597122 cites W2044107858 @default.
• W1995597122 cites W2044875682 @default.
• W1995597122 cites W2046824223 @default.
• W1995597122 cites W2049511526 @default.
• W1995597122 cites W2052850418 @default.
• W1995597122 cites W2053880874 @default.
• W1995597122 cites W2059714502 @default.
• W1995597122 cites W2062519880 @default.
• W1995597122 cites W2065140249 @default.
• W1995597122 cites W2065596380 @default.
• W1995597122 cites W2066083499 @default.
• W1995597122 cites W2072061003 @default.
• W1995597122 cites W2074293349 @default.
• W1995597122 cites W2075068003 @default.
• W1995597122 cites W2077797084 @default.
• W1995597122 cites W2085976634 @default.
• W1995597122 cites W2091134987 @default.
• W1995597122 cites W2091693001 @default.
• W1995597122 cites W2095516027 @default.
• W1995597122 cites W2104782649 @default.
• W1995597122 cites W2105711200 @default.
• W1995597122 cites W2107732949 @default.
• W1995597122 cites W2112515581 @default.
• W1995597122 cites W2117396078 @default.
• W1995597122 cites W2130188089 @default.
• W1995597122 cites W2134278083 @default.
• W1995597122 cites W2136937007 @default.
• W1995597122 cites W2140959932 @default.
• W1995597122 cites W2146896966 @default.
• W1995597122 cites W2148389554 @default.
• W1995597122 cites W2164784351 @default.
• W1995597122 cites W2167854172 @default.
• W1995597122 cites W2169916014 @default.
• W1995597122 cites W2170597465 @default.
• W1995597122 cites W2172527495 @default.
• W1995597122 cites W2319571450 @default.
• W1995597122 cites W4251324165 @default.
• W1995597122 doi "https://doi.org/10.1016/j.ejphar.2007.02.008" @default.
• W1995597122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17362916" @default.
• W1995597122 hasPublicationYear "2007" @default.
• W1995597122 type Work @default.
• W1995597122 sameAs 1995597122 @default.
• W1995597122 citedByCount "35" @default.
• W1995597122 countsByYear W19955971222012 @default.
• W1995597122 countsByYear W19955971222013 @default.
• W1995597122 countsByYear W19955971222014 @default.
• W1995597122 countsByYear W19955971222015 @default.
• W1995597122 countsByYear W19955971222016 @default.
• W1995597122 countsByYear W19955971222018 @default.
• W1995597122 countsByYear W19955971222019 @default.
• W1995597122 countsByYear W19955971222020 @default.
• W1995597122 countsByYear W19955971222021 @default.
• W1995597122 countsByYear W19955971222022 @default.
• W1995597122 crossrefType "journal-article" @default.
• W1995597122 hasAuthorship W1995597122A5013212790 @default.
• W1995597122 hasAuthorship W1995597122A5022251174 @default.

• next