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- W1995599088 abstract "In this review, we draw on literature from both animal and human neurophysiological studies to consider the neurochemical mechanisms underlying attention-deficit/ hyperactivity disorder (ADHD). Psychophysiological and neuropsychological research is used to propose possible etiological endophenotypes of ADHD. These are conceptualized as patients with distinct cortical-arousal, information-processing or maturational abnormalities, or a combination thereof, and how the endophenotypes can be used to help drug development and optimize treatment and management. To illustrate, the paper focuses on neuro- and psychophysiological evidence that suggests cholinergic mechanisms may underlie specific information-processing abnormalities that occur in ADHD. The clinical implications for a cholinergic hypothesis of ADHD are considered, along with its possible implications for treatment and pharmacological development." @default.
- W1995599088 created "2016-06-24" @default.
- W1995599088 creator A5004125472 @default.
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- W1995599088 date "2006-11-01" @default.
- W1995599088 modified "2023-09-27" @default.
- W1995599088 title "Attention-deficit/hyperactivity disorder: neurophysiology, information processing, arousal and drug development" @default.
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