Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995601087> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1995601087 endingPage "620" @default.
- W1995601087 startingPage "616" @default.
- W1995601087 abstract "<h2>Abstract</h2> A rat model has been developed to study the local effects of burn injury on the underlying muscle tissue. Protein turnover was measured in soleus muscle incubated in vitro in which both tyrosine release and protein synthesis was measured. A scald injury (3 seconds) to a small area of one hindlimb produces an increase in muscle proteolysis and is without effect on the soleus muscle of the contralateral leg. A very high concentration of indomethacin (40 μmol/L) had no effect on proteolysis in the control muscle but specifically inhibited burn-induced protein breakdown. However, since other cyclooxygenase inhibitors (aspirin and ibuprofen), lipoxygenase inhibitors (ETYA, NDGA, and esculetin), and mepacrine (a phospholipase inhibitor) had no effect on protein breakdown, it is unlikely that a product of arachidonic acid metabolism maintains the increased proteolysis in vitro. In addition, endogenous production of prostaglandin E2 (PGE2) was not different in muscles from burned and control legs. Probes of the proteolytic pathway using inhibitors show that the burn-induced stimulation of proteolysis is consistent with the stimulation of lysosomal protease activity. These results are supported by the observation of increased acid protease activity in muscle homogenates from the burned leg. The best hypothesis that explains these data is that a lysosomal pathway of protein degradation may be enhanced by burn. Products of arachidonic acid metabolism do not appear to maintain burn-induced proteolysis in muscle, although their role in initiating the pathological changes in vivo cannot be excluded." @default.
- W1995601087 created "2016-06-24" @default.
- W1995601087 creator A5090693812 @default.
- W1995601087 date "1985-07-01" @default.
- W1995601087 modified "2023-09-30" @default.
- W1995601087 title "Effect of inhibitors of proteolysis and arachidonic acid metabolism on burn-induced protein breakdown" @default.
- W1995601087 cites W1484675846 @default.
- W1995601087 cites W1506440892 @default.
- W1995601087 cites W1524946685 @default.
- W1995601087 cites W1577717356 @default.
- W1995601087 cites W1605024684 @default.
- W1995601087 cites W1681535119 @default.
- W1995601087 cites W1978212032 @default.
- W1995601087 cites W1996297374 @default.
- W1995601087 cites W2036930352 @default.
- W1995601087 cites W2085384544 @default.
- W1995601087 cites W2316398848 @default.
- W1995601087 cites W4301352296 @default.
- W1995601087 cites W52291163 @default.
- W1995601087 doi "https://doi.org/10.1016/0026-0495(85)90087-3" @default.
- W1995601087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3925289" @default.
- W1995601087 hasPublicationYear "1985" @default.
- W1995601087 type Work @default.
- W1995601087 sameAs 1995601087 @default.
- W1995601087 citedByCount "12" @default.
- W1995601087 crossrefType "journal-article" @default.
- W1995601087 hasAuthorship W1995601087A5090693812 @default.
- W1995601087 hasConcept C126322002 @default.
- W1995601087 hasConcept C134018914 @default.
- W1995601087 hasConcept C141071460 @default.
- W1995601087 hasConcept C181199279 @default.
- W1995601087 hasConcept C185592680 @default.
- W1995601087 hasConcept C24998067 @default.
- W1995601087 hasConcept C2776551241 @default.
- W1995601087 hasConcept C2776714187 @default.
- W1995601087 hasConcept C2778078955 @default.
- W1995601087 hasConcept C2779689624 @default.
- W1995601087 hasConcept C2780857362 @default.
- W1995601087 hasConcept C2781307694 @default.
- W1995601087 hasConcept C2992195973 @default.
- W1995601087 hasConcept C2993242423 @default.
- W1995601087 hasConcept C55493867 @default.
- W1995601087 hasConcept C71924100 @default.
- W1995601087 hasConcept C86803240 @default.
- W1995601087 hasConceptScore W1995601087C126322002 @default.
- W1995601087 hasConceptScore W1995601087C134018914 @default.
- W1995601087 hasConceptScore W1995601087C141071460 @default.
- W1995601087 hasConceptScore W1995601087C181199279 @default.
- W1995601087 hasConceptScore W1995601087C185592680 @default.
- W1995601087 hasConceptScore W1995601087C24998067 @default.
- W1995601087 hasConceptScore W1995601087C2776551241 @default.
- W1995601087 hasConceptScore W1995601087C2776714187 @default.
- W1995601087 hasConceptScore W1995601087C2778078955 @default.
- W1995601087 hasConceptScore W1995601087C2779689624 @default.
- W1995601087 hasConceptScore W1995601087C2780857362 @default.
- W1995601087 hasConceptScore W1995601087C2781307694 @default.
- W1995601087 hasConceptScore W1995601087C2992195973 @default.
- W1995601087 hasConceptScore W1995601087C2993242423 @default.
- W1995601087 hasConceptScore W1995601087C55493867 @default.
- W1995601087 hasConceptScore W1995601087C71924100 @default.
- W1995601087 hasConceptScore W1995601087C86803240 @default.
- W1995601087 hasIssue "7" @default.
- W1995601087 hasLocation W19956010871 @default.
- W1995601087 hasLocation W19956010872 @default.
- W1995601087 hasOpenAccess W1995601087 @default.
- W1995601087 hasPrimaryLocation W19956010871 @default.
- W1995601087 hasRelatedWork W1504870841 @default.
- W1995601087 hasRelatedWork W1995601087 @default.
- W1995601087 hasRelatedWork W2009454127 @default.
- W1995601087 hasRelatedWork W2021474461 @default.
- W1995601087 hasRelatedWork W2026574739 @default.
- W1995601087 hasRelatedWork W2059429489 @default.
- W1995601087 hasRelatedWork W2061707259 @default.
- W1995601087 hasRelatedWork W2412984830 @default.
- W1995601087 hasRelatedWork W2516373692 @default.
- W1995601087 hasRelatedWork W284529333 @default.
- W1995601087 hasVolume "34" @default.
- W1995601087 isParatext "false" @default.
- W1995601087 isRetracted "false" @default.
- W1995601087 magId "1995601087" @default.
- W1995601087 workType "article" @default.