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• W1995619785 abstract "Frog spinal motoneurones were studied in vitro under voltage clamp conditions to examine the effect of the peptide thyrotropin-releasing hormone (TRH). TRH (50 μM) produced a small membrane depolarization, without obvious changes in the neuronal conductance or sensitivity to exogenously applied glutamate. These effects were seen regardless of the presence of 1 mM Mg2+ in the bathing solution. Low-and high-threshold excitatory postsynaptic potentials, induced by dorsal root stimulation, were enhanced by TRH. Under voltage clamp, TRH did not change the cell leak conductance while producing a considerable enhancement of polysynaptic current amplitude, particulary when recorded at a rather negative potential level. It is suggested that TRH might potentiate excitatory neurotransmission by facilitating presynaptic release of the excitatory neurotransmitter(s) onto motoneurones." @default.
• W1995619785 created "2016-06-24" @default.
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• W1995619785 creator A5042838362 @default.
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• W1995619785 date "1989-05-01" @default.
• W1995619785 modified "2023-09-23" @default.
• W1995619785 title "Large enhancement of excitatory postsynaptic potentials and currents by thyrotropin-releasing hormone (TRH) in frog spinal motoneurones" @default.
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• W1995619785 doi "https://doi.org/10.1016/0006-8993(89)90695-1" @default.
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• W1995619785 hasPublicationYear "1989" @default.
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