Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995621627> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1995621627 endingPage "236" @default.
- W1995621627 startingPage "227" @default.
- W1995621627 abstract "A high capacity in vitro micronucleus assay was developed to evaluate the ability of selected 6-fluorinated quinolone and naphthyridone antibacterial compounds to induce micronuclei (MN) in vitro in V79 Chinese hamster lung cells. Log-phase cells in six-well cluster dishes were exposed for 3 h in the absence of S9 to 34 compounds. After treatment, cells were refed with media containing cytochalasin B, incubated for 16 h, and harvested for cell-cycle kinetics (CCK) and MN analyses. The quinolones tested were grouped according to the substituent at the 8-position. All 4 compounds having a halogen substitution at position 8, five of the six 8-trifluoromethyl quinolones, and all eight 8-methoxy-substituted compounds induced a significant increase in MN. Only 5 of the 10 naphthyridone compounds tested, having a variety of substituents at the 7-position, were inducers of MN and the overall magnitude of the response was less than with the quinolones. The minimum clastogenic concentration for the quinolones ranged from 4 to 400 micrograms/ml and for the naphthyridones this range was from 22.5 to 100 micrograms/ml. In the groups examined, napthyridone compounds were less likely than quinolones to induce in vitro MN, particularly when the substituent at the 7-position in the naphthyridone contains some bulk (methyl groups) around the amine side-chain. Most of the quinolones tested induced MN, irrespective of the substituents at positions 7 or 8." @default.
- W1995621627 created "2016-06-24" @default.
- W1995621627 creator A5017848602 @default.
- W1995621627 creator A5048342481 @default.
- W1995621627 creator A5088900978 @default.
- W1995621627 date "1993-02-01" @default.
- W1995621627 modified "2023-09-25" @default.
- W1995621627 title "High capacity in vitro micronucleus assay for assessment of chromosome damage: results with quinolone / naphthyridone antibacterials" @default.
- W1995621627 cites W1965724734 @default.
- W1995621627 cites W1991523142 @default.
- W1995621627 cites W2004994748 @default.
- W1995621627 cites W2014818689 @default.
- W1995621627 cites W2016277572 @default.
- W1995621627 cites W2016279114 @default.
- W1995621627 cites W2024348557 @default.
- W1995621627 cites W2055499537 @default.
- W1995621627 cites W2056204961 @default.
- W1995621627 cites W2082939120 @default.
- W1995621627 cites W4300768864 @default.
- W1995621627 doi "https://doi.org/10.1016/0165-1218(93)90001-t" @default.
- W1995621627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7678158" @default.
- W1995621627 hasPublicationYear "1993" @default.
- W1995621627 type Work @default.
- W1995621627 sameAs 1995621627 @default.
- W1995621627 citedByCount "27" @default.
- W1995621627 countsByYear W19956216272012 @default.
- W1995621627 countsByYear W19956216272014 @default.
- W1995621627 countsByYear W19956216272023 @default.
- W1995621627 crossrefType "journal-article" @default.
- W1995621627 hasAuthorship W1995621627A5017848602 @default.
- W1995621627 hasAuthorship W1995621627A5048342481 @default.
- W1995621627 hasAuthorship W1995621627A5088900978 @default.
- W1995621627 hasConcept C141710004 @default.
- W1995621627 hasConcept C178790620 @default.
- W1995621627 hasConcept C185592680 @default.
- W1995621627 hasConcept C202751555 @default.
- W1995621627 hasConcept C2777366897 @default.
- W1995621627 hasConcept C2777755551 @default.
- W1995621627 hasConcept C2778689049 @default.
- W1995621627 hasConcept C2779922871 @default.
- W1995621627 hasConcept C29730261 @default.
- W1995621627 hasConcept C36681516 @default.
- W1995621627 hasConcept C45080847 @default.
- W1995621627 hasConcept C501593827 @default.
- W1995621627 hasConcept C55493867 @default.
- W1995621627 hasConcept C71240020 @default.
- W1995621627 hasConceptScore W1995621627C141710004 @default.
- W1995621627 hasConceptScore W1995621627C178790620 @default.
- W1995621627 hasConceptScore W1995621627C185592680 @default.
- W1995621627 hasConceptScore W1995621627C202751555 @default.
- W1995621627 hasConceptScore W1995621627C2777366897 @default.
- W1995621627 hasConceptScore W1995621627C2777755551 @default.
- W1995621627 hasConceptScore W1995621627C2778689049 @default.
- W1995621627 hasConceptScore W1995621627C2779922871 @default.
- W1995621627 hasConceptScore W1995621627C29730261 @default.
- W1995621627 hasConceptScore W1995621627C36681516 @default.
- W1995621627 hasConceptScore W1995621627C45080847 @default.
- W1995621627 hasConceptScore W1995621627C501593827 @default.
- W1995621627 hasConceptScore W1995621627C55493867 @default.
- W1995621627 hasConceptScore W1995621627C71240020 @default.
- W1995621627 hasIssue "4" @default.
- W1995621627 hasLocation W19956216271 @default.
- W1995621627 hasLocation W19956216272 @default.
- W1995621627 hasOpenAccess W1995621627 @default.
- W1995621627 hasPrimaryLocation W19956216271 @default.
- W1995621627 hasRelatedWork W1994910955 @default.
- W1995621627 hasRelatedWork W1995621627 @default.
- W1995621627 hasRelatedWork W2009599788 @default.
- W1995621627 hasRelatedWork W2037592385 @default.
- W1995621627 hasRelatedWork W2112560233 @default.
- W1995621627 hasRelatedWork W2130235189 @default.
- W1995621627 hasRelatedWork W2154771600 @default.
- W1995621627 hasRelatedWork W2162213622 @default.
- W1995621627 hasRelatedWork W2512876640 @default.
- W1995621627 hasRelatedWork W809441913 @default.
- W1995621627 hasVolume "298" @default.
- W1995621627 isParatext "false" @default.
- W1995621627 isRetracted "false" @default.
- W1995621627 magId "1995621627" @default.
- W1995621627 workType "article" @default.