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• W1995622522 endingPage "2297" @default.
• W1995622522 startingPage "2283" @default.
• W1995622522 abstract "Angiogenesis is fundamental to physiological and pathological processes. Despite intensive efforts, little is known about the intracellular circuits that regulate angiogenesis. The transcription factor Net is activated by phosphorylation induced by Ras, an indirect regulator of angiogenesis. Net is expressed at sites of vasculogenesis and angiogenesis during early mouse development, suggesting that it could have a role in blood vessel formation. We show here that down-regulation of Net inhibits angiogenesis and vascular endothelial growth factor (VEGF) expression in vivo, ex vivo, and in vitro. Ras-activated phosphorylated Net (P-Net) stimulates the mouse VEGF promoter through the -80 to -53 region that principally binds Sp1. P-Net and VEGF are coexpressed in angiogenic processes in wild-type mouse tissues and in human tumors. We conclude that Net is a regulator of angiogenesis that can switch to an activator following induction by pro-angiogenic molecules." @default.
• W1995622522 created "2016-06-24" @default.
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• W1995622522 date "2003-09-15" @default.
• W1995622522 modified "2023-10-15" @default.
• W1995622522 title "The transcription factor Net regulates the angiogenic switch" @default.
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• W1995622522 doi "https://doi.org/10.1101/gad.272503" @default.
• W1995622522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/196465" @default.
• W1995622522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12975317" @default.
• W1995622522 hasPublicationYear "2003" @default.

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