FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995630012> ?p ?o ?g. }

• W1995630012 endingPage "105" @default.
• W1995630012 startingPage "99" @default.
• W1995630012 abstract "According to Pearson’s HSAB (hard and soft acids and bases) rule, the vanadyl ion is classified as a hard acid. However, vanadyl–cysteine methyl ester and dithiocarbamate complexes with VO(S2N2) and VO(S4) coordination modes, respectively, that contain bonds with a combination of hard acid (VO2+) and soft base (sulfur) have been found to form stable complexes and exhibit insulin-mimetic activities in in vitro and in vivo evaluations. Based on such observations, a purple bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) (VO(OPT)) complex with VO(S2O2) coordination mode was prepared and found to have a strong insulin-mimetic activity in in vitro evaluation, which followed in vivo effectiveness on intraperitoneal injection and oral administration. Then, we examined the real-time ESR analysis of vanadyl species in the blood of live rats given VO(OPT) by use of the blood circulation monitoring-ESR method. The clearance of vanadyl species from the blood in terms of half-life (t1/2) was determined as 15 min in VO(OPT)-treated rats, while t1/2 of VOSO4-treated rats was 5 min, indicating the long-term acting character of VO(OPT). On the basis of the results, VO(OPT) with VO(S2O2) coordination mode is proposed to be a potent orally active insulin-mimetic complex in treating insulin-dependent diabetes mellitus in experimental animals." @default.
• W1995630012 created "2016-06-24" @default.
• W1995630012 creator A5008610426 @default.
• W1995630012 creator A5065473510 @default.
• W1995630012 creator A5070814001 @default.
• W1995630012 creator A5074053074 @default.
• W1995630012 date "2000-05-01" @default.
• W1995630012 modified "2023-10-12" @default.
• W1995630012 title "An orally active antidiabetic vanadyl complex, bis(1-oxy-2-pyridinethiolato)oxovanadium(IV), with VO(S2O2) coordination mode; in vitro and in vivo evaluations in rats" @default.
• W1995630012 cites W1484619869 @default.
• W1995630012 cites W1967307772 @default.
• W1995630012 cites W1978315699 @default.
• W1995630012 cites W1978734163 @default.
• W1995630012 cites W1981195135 @default.
• W1995630012 cites W198289730 @default.
• W1995630012 cites W1992762994 @default.
• W1995630012 cites W1997809992 @default.
• W1995630012 cites W2005877813 @default.
• W1995630012 cites W2013562553 @default.
• W1995630012 cites W2030526034 @default.
• W1995630012 cites W2032108914 @default.
• W1995630012 cites W2033361896 @default.
• W1995630012 cites W2039707682 @default.
• W1995630012 cites W2067496936 @default.
• W1995630012 cites W2069302519 @default.
• W1995630012 cites W2075810197 @default.
• W1995630012 cites W2080786846 @default.
• W1995630012 cites W2087526401 @default.
• W1995630012 cites W2092654177 @default.
• W1995630012 cites W2233175606 @default.
• W1995630012 cites W2949686205 @default.
• W1995630012 doi "https://doi.org/10.1016/s0162-0134(00)00045-3" @default.
• W1995630012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10885469" @default.
• W1995630012 hasPublicationYear "2000" @default.
• W1995630012 type Work @default.
• W1995630012 sameAs 1995630012 @default.
• W1995630012 citedByCount "96" @default.
• W1995630012 countsByYear W19956300122012 @default.
• W1995630012 countsByYear W19956300122013 @default.
• W1995630012 countsByYear W19956300122014 @default.
• W1995630012 countsByYear W19956300122015 @default.
• W1995630012 countsByYear W19956300122016 @default.
• W1995630012 countsByYear W19956300122017 @default.
• W1995630012 countsByYear W19956300122018 @default.
• W1995630012 countsByYear W19956300122019 @default.
• W1995630012 countsByYear W19956300122020 @default.
• W1995630012 countsByYear W19956300122021 @default.
• W1995630012 countsByYear W19956300122022 @default.
• W1995630012 countsByYear W19956300122023 @default.
• W1995630012 crossrefType "journal-article" @default.
• W1995630012 hasAuthorship W1995630012A5008610426 @default.
• W1995630012 hasAuthorship W1995630012A5065473510 @default.
• W1995630012 hasAuthorship W1995630012A5070814001 @default.
• W1995630012 hasAuthorship W1995630012A5074053074 @default.
• W1995630012 hasConcept C126322002 @default.
• W1995630012 hasConcept C134018914 @default.
• W1995630012 hasConcept C150903083 @default.
• W1995630012 hasConcept C155647269 @default.
• W1995630012 hasConcept C185592680 @default.
• W1995630012 hasConcept C202751555 @default.
• W1995630012 hasConcept C207001950 @default.
• W1995630012 hasConcept C2779306644 @default.
• W1995630012 hasConcept C55493867 @default.
• W1995630012 hasConcept C555293320 @default.
• W1995630012 hasConcept C71240020 @default.
• W1995630012 hasConcept C71924100 @default.
• W1995630012 hasConcept C86803240 @default.
• W1995630012 hasConceptScore W1995630012C126322002 @default.
• W1995630012 hasConceptScore W1995630012C134018914 @default.
• W1995630012 hasConceptScore W1995630012C150903083 @default.
• W1995630012 hasConceptScore W1995630012C155647269 @default.
• W1995630012 hasConceptScore W1995630012C185592680 @default.
• W1995630012 hasConceptScore W1995630012C202751555 @default.
• W1995630012 hasConceptScore W1995630012C207001950 @default.
• W1995630012 hasConceptScore W1995630012C2779306644 @default.
• W1995630012 hasConceptScore W1995630012C55493867 @default.
• W1995630012 hasConceptScore W1995630012C555293320 @default.
• W1995630012 hasConceptScore W1995630012C71240020 @default.
• W1995630012 hasConceptScore W1995630012C71924100 @default.
• W1995630012 hasConceptScore W1995630012C86803240 @default.
• W1995630012 hasFunder F4320320912 @default.
• W1995630012 hasIssue "1-2" @default.
• W1995630012 hasLocation W19956300121 @default.
• W1995630012 hasLocation W19956300122 @default.
• W1995630012 hasOpenAccess W1995630012 @default.
• W1995630012 hasPrimaryLocation W19956300121 @default.
• W1995630012 hasRelatedWork W1566729005 @default.
• W1995630012 hasRelatedWork W1700716001 @default.
• W1995630012 hasRelatedWork W2013908504 @default.
• W1995630012 hasRelatedWork W2054843986 @default.
• W1995630012 hasRelatedWork W2116210813 @default.
• W1995630012 hasRelatedWork W2138350991 @default.
• W1995630012 hasRelatedWork W2409285845 @default.
• W1995630012 hasRelatedWork W2434195791 @default.
• W1995630012 hasRelatedWork W2440701365 @default.
• W1995630012 hasRelatedWork W3015376786 @default.
• W1995630012 hasVolume "80" @default.
• W1995630012 isParatext "false" @default.

• next