FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995637638> ?p ?o ?g. }

• W1995637638 endingPage "61" @default.
• W1995637638 startingPage "52" @default.
• W1995637638 abstract "The mu opioid receptor (MOR) is the principle molecular target of opioid analgesics. The polypyrimidine/polypurine (PPy/u) motif enhances the activity of the MOR gene promoter by adopting a non-B DNA conformation. Here, we report that the PPy/u motif regulates the processivity of torsional stress, which is important for endogenous MOR gene expression. Analysis by topoisomerase assays, S1 nuclease digests, and atomic force microscopy showed that, unlike homologous PPy/u motifs, the position- and orientation-induced structural strains to the mouse PPy/u element affect its ability to perturb the relaxation activity of topoisomerase, resulting in polypurine strand-nicked and catenated DNA conformations. Raman spectrum microscopy confirmed that mouse PPy/u containing-plasmid DNA molecules under the different structural strains have a different configuration of ring bases as well as altered Hoogsteen hydrogen bonds. The mouse MOR PPy/u motif drives reporter gene expression fortyfold more effectively in the sense orientation than in the antisense orientation. Furthermore, mouse neuronal cells activate MOR gene expression in response to the perturbations of topology by topoisomerase inhibitors, whereas human cells do not. These results suggest that, interestingly among homologous PPy/u motifs, the mouse MOR PPy/u motif dynamically responds to torsional stress and consequently regulates MOR gene expression in vivo." @default.
• W1995637638 created "2016-06-24" @default.
• W1995637638 creator A5008755139 @default.
• W1995637638 creator A5014354004 @default.
• W1995637638 creator A5042950704 @default.
• W1995637638 creator A5085795892 @default.
• W1995637638 creator A5086547366 @default.
• W1995637638 creator A5091510144 @default.
• W1995637638 date "2011-11-01" @default.
• W1995637638 modified "2023-10-14" @default.
• W1995637638 title "The polypyrimidine/polypurine motif in the mouse mu opioid receptor gene promoter is a supercoiling-regulatory element" @default.
• W1995637638 cites W155301420 @default.
• W1995637638 cites W1970419257 @default.
• W1995637638 cites W1974470327 @default.
• W1995637638 cites W1976108512 @default.
• W1995637638 cites W1980480427 @default.
• W1995637638 cites W1988140192 @default.
• W1995637638 cites W1989118916 @default.
• W1995637638 cites W1990154423 @default.
• W1995637638 cites W1994064477 @default.
• W1995637638 cites W1999364887 @default.
• W1995637638 cites W2005030095 @default.
• W1995637638 cites W2014048071 @default.
• W1995637638 cites W2018076609 @default.
• W1995637638 cites W2023820135 @default.
• W1995637638 cites W2027143034 @default.
• W1995637638 cites W2028607541 @default.
• W1995637638 cites W2028727595 @default.
• W1995637638 cites W2029147651 @default.
• W1995637638 cites W2036002146 @default.
• W1995637638 cites W2038535670 @default.
• W1995637638 cites W2046910065 @default.
• W1995637638 cites W2052143549 @default.
• W1995637638 cites W2061650274 @default.
• W1995637638 cites W2069340648 @default.
• W1995637638 cites W2074139680 @default.
• W1995637638 cites W2082863705 @default.
• W1995637638 cites W2091293786 @default.
• W1995637638 cites W2091661991 @default.
• W1995637638 cites W2099090001 @default.
• W1995637638 cites W2103791221 @default.
• W1995637638 cites W2118187735 @default.
• W1995637638 cites W2129817345 @default.
• W1995637638 cites W2132052491 @default.
• W1995637638 cites W2143833086 @default.
• W1995637638 cites W2150612809 @default.
• W1995637638 cites W2167620625 @default.
• W1995637638 cites W2409166770 @default.
• W1995637638 cites W4231425765 @default.
• W1995637638 cites W4246900972 @default.
• W1995637638 doi "https://doi.org/10.1016/j.gene.2011.07.026" @default.
• W1995637638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3711265" @default.
• W1995637638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21839154" @default.
• W1995637638 hasPublicationYear "2011" @default.
• W1995637638 type Work @default.
• W1995637638 sameAs 1995637638 @default.
• W1995637638 citedByCount "4" @default.
• W1995637638 countsByYear W19956376382012 @default.
• W1995637638 countsByYear W19956376382013 @default.
• W1995637638 countsByYear W19956376382022 @default.
• W1995637638 crossrefType "journal-article" @default.
• W1995637638 hasAuthorship W1995637638A5008755139 @default.
• W1995637638 hasAuthorship W1995637638A5014354004 @default.
• W1995637638 hasAuthorship W1995637638A5042950704 @default.
• W1995637638 hasAuthorship W1995637638A5085795892 @default.
• W1995637638 hasAuthorship W1995637638A5086547366 @default.
• W1995637638 hasAuthorship W1995637638A5091510144 @default.
• W1995637638 hasBestOaLocation W19956376382 @default.
• W1995637638 hasConcept C104317684 @default.
• W1995637638 hasConcept C147897179 @default.
• W1995637638 hasConcept C150194340 @default.
• W1995637638 hasConcept C153911025 @default.
• W1995637638 hasConcept C158456008 @default.
• W1995637638 hasConcept C161733203 @default.
• W1995637638 hasConcept C552990157 @default.
• W1995637638 hasConcept C55493867 @default.
• W1995637638 hasConcept C73573662 @default.
• W1995637638 hasConcept C86803240 @default.
• W1995637638 hasConcept C95444343 @default.
• W1995637638 hasConceptScore W1995637638C104317684 @default.
• W1995637638 hasConceptScore W1995637638C147897179 @default.
• W1995637638 hasConceptScore W1995637638C150194340 @default.
• W1995637638 hasConceptScore W1995637638C153911025 @default.
• W1995637638 hasConceptScore W1995637638C158456008 @default.
• W1995637638 hasConceptScore W1995637638C161733203 @default.
• W1995637638 hasConceptScore W1995637638C552990157 @default.
• W1995637638 hasConceptScore W1995637638C55493867 @default.
• W1995637638 hasConceptScore W1995637638C73573662 @default.
• W1995637638 hasConceptScore W1995637638C86803240 @default.
• W1995637638 hasConceptScore W1995637638C95444343 @default.
• W1995637638 hasIssue "1" @default.
• W1995637638 hasLocation W19956376381 @default.
• W1995637638 hasLocation W19956376382 @default.
• W1995637638 hasLocation W19956376383 @default.
• W1995637638 hasLocation W19956376384 @default.
• W1995637638 hasOpenAccess W1995637638 @default.
• W1995637638 hasPrimaryLocation W19956376381 @default.
• W1995637638 hasRelatedWork W1979668375 @default.

• next