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• W1995650385 abstract "ABSTRACT Proteus mirabilis is a urinary tract pathogen that differentiates from a short swimmer cell to an elongated, highly flagellated swarmer cell. Swarmer cell differentiation parallels an increased expression of several virulence factors, suggesting that both processes are controlled by the same signal. The molecular nature of this signal is not known but is hypothesized to involve the inhibition of flagellar rotation. In this study, data are presented supporting the idea that conditions inhibiting flagellar rotation induce swarmer cell differentiation and implicating a rotating flagellar filament as critical to the sensing mechanism. Mutations in three genes, fliL , fliF , and fliG , encoding components of the flagellar basal body, result in the inappropriate development of swarmer cells in noninducing liquid media or hyperelongated swarmer cells on agar media. The fliL mutation was studied in detail. FliL − mutants are nonmotile and fail to synthesize flagellin, while complementation of fliL restores wild-type cell elongation but not motility. Overexpression of fliL + in wild-type cells prevents swarmer cell differentiation and motility, a result also observed when P. mirabilis fliL + was expressed in Escherichia coli . These results suggest that FliL plays a role in swarmer cell differentiation and implicate FliL as critical to transduction of the signal inducing swarmer cell differentiation and virulence gene expression. In concert with this idea, defects in fliL up-regulate the expression of two virulence genes, zapA and hpmB . These results support the hypothesis that P. mirabilis ascertains its location in the environment or host by assessing the status of its flagellar motors, which in turn control swarmer cell gene expression." @default.
• W1995650385 created "2016-06-24" @default.
• W1995650385 creator A5016060373 @default.
• W1995650385 creator A5033211665 @default.
• W1995650385 date "2005-10-01" @default.
• W1995650385 modified "2023-09-29" @default.
• W1995650385 title "The Ability of <i>Proteus mirabilis</i> To Sense Surfaces and Regulate Virulence Gene Expression Involves FliL, a Flagellar Basal Body Protein" @default.
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• W1995650385 doi "https://doi.org/10.1128/jb.187.19.6789-6803.2005" @default.
• W1995650385 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1251568" @default.
• W1995650385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16166542" @default.
• W1995650385 hasPublicationYear "2005" @default.
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