FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995656483> ?p ?o ?g. }

• W1995656483 endingPage "51" @default.
• W1995656483 startingPage "37" @default.
• W1995656483 abstract "We used a relatively small library of 5520 randomly generated single 15-mer peptides prepared by SPOT synthesis as an array of 28.5x19.0 cm to identify epitopes for three distinct monoclonal antibodies, namely anti-p24 (human immunodeficiency virus (HIV)-1) monoclonal anibody (mab) CB4-1, anti-interleukin-10 (IL-10) mab CB/RS/13, and anti-transforming growth factor alpha (TGFalpha) mab Tab2. Initially identified peptide ligands mostly had very low affinities for the antibodies with dissociation constants around 10(-4) M. Subsequent identification of residues critical for the antibody interactions involved complete L-amino acid substitutional analyses. Several substitutions resulted in analogs with dissociation constants in the low micromolar and high nanomolar range. Specifically binding peptides with key residue patterns matching the wild-type epitopes were identified for all three antibodies. In addition, for antibody CB4-1 mimotopes that showed no homology to the known epitope were selected. Our results suggest that a very limited library diversity, although far from covering the entire sequence repertoire, can suffice to rapidly and economically select peptidic antibody epitopes and mimotopes." @default.
• W1995656483 created "2016-06-24" @default.
• W1995656483 creator A5013874274 @default.
• W1995656483 creator A5016221670 @default.
• W1995656483 creator A5017359762 @default.
• W1995656483 creator A5018532546 @default.
• W1995656483 creator A5040914776 @default.
• W1995656483 creator A5054779878 @default.
• W1995656483 creator A5065510179 @default.
• W1995656483 creator A5074792644 @default.
• W1995656483 creator A5084334734 @default.
• W1995656483 date "2002-09-01" @default.
• W1995656483 modified "2023-10-09" @default.
• W1995656483 title "Identification of distinct antibody epitopes and mimotopes from a peptide array of 5520 randomly generated sequences" @default.
• W1995656483 cites W116322834 @default.
• W1995656483 cites W1511116368 @default.
• W1995656483 cites W1964048941 @default.
• W1995656483 cites W1976801077 @default.
• W1995656483 cites W1981898410 @default.
• W1995656483 cites W1995910393 @default.
• W1995656483 cites W2002589504 @default.
• W1995656483 cites W2005596497 @default.
• W1995656483 cites W2006446936 @default.
• W1995656483 cites W2010649076 @default.
• W1995656483 cites W2013404658 @default.
• W1995656483 cites W2022257442 @default.
• W1995656483 cites W2028493269 @default.
• W1995656483 cites W2030189518 @default.
• W1995656483 cites W2041217671 @default.
• W1995656483 cites W2041719513 @default.
• W1995656483 cites W2055708140 @default.
• W1995656483 cites W2059230162 @default.
• W1995656483 cites W2061507382 @default.
• W1995656483 cites W2065236789 @default.
• W1995656483 cites W2067920323 @default.
• W1995656483 cites W2073607947 @default.
• W1995656483 cites W2080262597 @default.
• W1995656483 cites W2080584551 @default.
• W1995656483 cites W2087599118 @default.
• W1995656483 cites W2091067968 @default.
• W1995656483 cites W2126905278 @default.
• W1995656483 cites W2145917533 @default.
• W1995656483 cites W2148404862 @default.
• W1995656483 cites W2149464124 @default.
• W1995656483 cites W4211045835 @default.
• W1995656483 doi "https://doi.org/10.1016/s0022-1759(02)00139-4" @default.
• W1995656483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12135799" @default.
• W1995656483 hasPublicationYear "2002" @default.
• W1995656483 type Work @default.
• W1995656483 sameAs 1995656483 @default.
• W1995656483 citedByCount "80" @default.
• W1995656483 countsByYear W19956564832012 @default.
• W1995656483 countsByYear W19956564832013 @default.
• W1995656483 countsByYear W19956564832014 @default.
• W1995656483 countsByYear W19956564832015 @default.
• W1995656483 countsByYear W19956564832016 @default.
• W1995656483 countsByYear W19956564832017 @default.
• W1995656483 countsByYear W19956564832018 @default.
• W1995656483 countsByYear W19956564832019 @default.
• W1995656483 crossrefType "journal-article" @default.
• W1995656483 hasAuthorship W1995656483A5013874274 @default.
• W1995656483 hasAuthorship W1995656483A5016221670 @default.
• W1995656483 hasAuthorship W1995656483A5017359762 @default.
• W1995656483 hasAuthorship W1995656483A5018532546 @default.
• W1995656483 hasAuthorship W1995656483A5040914776 @default.
• W1995656483 hasAuthorship W1995656483A5054779878 @default.
• W1995656483 hasAuthorship W1995656483A5065510179 @default.
• W1995656483 hasAuthorship W1995656483A5074792644 @default.
• W1995656483 hasAuthorship W1995656483A5084334734 @default.
• W1995656483 hasConcept C104317684 @default.
• W1995656483 hasConcept C153911025 @default.
• W1995656483 hasConcept C159047783 @default.
• W1995656483 hasConcept C159654299 @default.
• W1995656483 hasConcept C167625842 @default.
• W1995656483 hasConcept C185592680 @default.
• W1995656483 hasConcept C195616568 @default.
• W1995656483 hasConcept C2776471321 @default.
• W1995656483 hasConcept C2779281246 @default.
• W1995656483 hasConcept C2781241564 @default.
• W1995656483 hasConcept C542903549 @default.
• W1995656483 hasConcept C54355233 @default.
• W1995656483 hasConcept C55493867 @default.
• W1995656483 hasConcept C86803240 @default.
• W1995656483 hasConcept C9365378 @default.
• W1995656483 hasConceptScore W1995656483C104317684 @default.
• W1995656483 hasConceptScore W1995656483C153911025 @default.
• W1995656483 hasConceptScore W1995656483C159047783 @default.
• W1995656483 hasConceptScore W1995656483C159654299 @default.
• W1995656483 hasConceptScore W1995656483C167625842 @default.
• W1995656483 hasConceptScore W1995656483C185592680 @default.
• W1995656483 hasConceptScore W1995656483C195616568 @default.
• W1995656483 hasConceptScore W1995656483C2776471321 @default.
• W1995656483 hasConceptScore W1995656483C2779281246 @default.
• W1995656483 hasConceptScore W1995656483C2781241564 @default.
• W1995656483 hasConceptScore W1995656483C542903549 @default.
• W1995656483 hasConceptScore W1995656483C54355233 @default.
• W1995656483 hasConceptScore W1995656483C55493867 @default.
• W1995656483 hasConceptScore W1995656483C86803240 @default.

• next