FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995664887> ?p ?o ?g. }

• W1995664887 endingPage "683" @default.
• W1995664887 startingPage "675" @default.
• W1995664887 abstract "Background The role of temporary ovarian suppression with gonadotropin-releasing hormone analogues (GnRHa) in the prevention of chemotherapy-induced premature ovarian failure (POF) is still controversial. We conducted a systematic review and meta-analysis of randomized trials evaluating the efficacy of GnRHa, given before and during chemotherapy, in the prevention of POF in premenopausal cancer patients. Methods Studies were retrieved by searching PubMed, Web of Knowledge database and the proceedings of major conferences. We calculated Odds Ratios (OR) and 95% confidence intervals (CIs) for POF from each trial and obtained pooled estimates through the random effects model as suggested by DerSimonian and Laird. Results Nine studies were included in the meta-analysis with 225 events of POF occurring in 765 analyzed patients. The pooled OR estimate indicates a highly significant reduction in the risk of POF (OR = 0.43; 95% CI: 0.22–0.84; p = 0.013) in patients receiving GnRHa. There was statistically significant heterogeneity among studies (I2 = 55.8%; p = 0.012). There was no evidence of publication bias. Subgroups analyses showed that the protective effect of GnRHa against POF was similar in subgroups of patients defined by age and timing of POF assessment, while it was present in breast cancer but unclear in ovarian cancer and lymphoma patients. Conclusions Our pooled analysis of randomized studies shows that the temporary ovarian suppression induced by GnRHa significantly reduces the risk of chemotherapy-induced POF in young cancer patients." @default.
• W1995664887 created "2016-06-24" @default.
• W1995664887 creator A5007007404 @default.
• W1995664887 creator A5008306424 @default.
• W1995664887 creator A5013062135 @default.
• W1995664887 creator A5020297889 @default.
• W1995664887 creator A5023088198 @default.
• W1995664887 creator A5026665975 @default.
• W1995664887 creator A5039478541 @default.
• W1995664887 creator A5061664575 @default.
• W1995664887 creator A5074479074 @default.
• W1995664887 creator A5075594005 @default.
• W1995664887 creator A5082293621 @default.
• W1995664887 creator A5085649082 @default.
• W1995664887 creator A5091211004 @default.
• W1995664887 date "2014-06-01" @default.
• W1995664887 modified "2023-10-16" @default.
• W1995664887 title "Gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in cancer women: Systematic review and meta-analysis of randomized trials" @default.
• W1995664887 cites W1530466595 @default.
• W1995664887 cites W1577197107 @default.
• W1995664887 cites W1964972487 @default.
• W1995664887 cites W1982918167 @default.
• W1995664887 cites W1993519794 @default.
• W1995664887 cites W2010303851 @default.
• W1995664887 cites W2013310971 @default.
• W1995664887 cites W2031942208 @default.
• W1995664887 cites W2039418122 @default.
• W1995664887 cites W2043175212 @default.
• W1995664887 cites W2043822973 @default.
• W1995664887 cites W2048769612 @default.
• W1995664887 cites W2053062054 @default.
• W1995664887 cites W2062502423 @default.
• W1995664887 cites W2063572434 @default.
• W1995664887 cites W2081320515 @default.
• W1995664887 cites W2088996917 @default.
• W1995664887 cites W2099615704 @default.
• W1995664887 cites W2101897761 @default.
• W1995664887 cites W2107328434 @default.
• W1995664887 cites W2112844484 @default.
• W1995664887 cites W2117878780 @default.
• W1995664887 cites W2120335312 @default.
• W1995664887 cites W2126930838 @default.
• W1995664887 cites W2128780026 @default.
• W1995664887 cites W2133218300 @default.
• W1995664887 cites W2134748828 @default.
• W1995664887 cites W2137264912 @default.
• W1995664887 cites W2139473755 @default.
• W1995664887 cites W2140919995 @default.
• W1995664887 cites W2142075003 @default.
• W1995664887 cites W2142492290 @default.
• W1995664887 cites W2157486406 @default.
• W1995664887 cites W2157823046 @default.
• W1995664887 cites W2163383095 @default.
• W1995664887 cites W2273494532 @default.
• W1995664887 cites W2400139667 @default.
• W1995664887 doi "https://doi.org/10.1016/j.ctrv.2013.12.001" @default.
• W1995664887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24360817" @default.
• W1995664887 hasPublicationYear "2014" @default.
• W1995664887 type Work @default.
• W1995664887 sameAs 1995664887 @default.
• W1995664887 citedByCount "157" @default.
• W1995664887 countsByYear W19956648872014 @default.
• W1995664887 countsByYear W19956648872015 @default.
• W1995664887 countsByYear W19956648872016 @default.
• W1995664887 countsByYear W19956648872017 @default.
• W1995664887 countsByYear W19956648872018 @default.
• W1995664887 countsByYear W19956648872019 @default.
• W1995664887 countsByYear W19956648872020 @default.
• W1995664887 countsByYear W19956648872021 @default.
• W1995664887 countsByYear W19956648872022 @default.
• W1995664887 countsByYear W19956648872023 @default.
• W1995664887 crossrefType "journal-article" @default.
• W1995664887 hasAuthorship W1995664887A5007007404 @default.
• W1995664887 hasAuthorship W1995664887A5008306424 @default.
• W1995664887 hasAuthorship W1995664887A5013062135 @default.
• W1995664887 hasAuthorship W1995664887A5020297889 @default.
• W1995664887 hasAuthorship W1995664887A5023088198 @default.
• W1995664887 hasAuthorship W1995664887A5026665975 @default.
• W1995664887 hasAuthorship W1995664887A5039478541 @default.
• W1995664887 hasAuthorship W1995664887A5061664575 @default.
• W1995664887 hasAuthorship W1995664887A5074479074 @default.
• W1995664887 hasAuthorship W1995664887A5075594005 @default.
• W1995664887 hasAuthorship W1995664887A5082293621 @default.
• W1995664887 hasAuthorship W1995664887A5085649082 @default.
• W1995664887 hasAuthorship W1995664887A5091211004 @default.
• W1995664887 hasConcept C121608353 @default.
• W1995664887 hasConcept C126322002 @default.
• W1995664887 hasConcept C143998085 @default.
• W1995664887 hasConcept C156957248 @default.
• W1995664887 hasConcept C168563851 @default.
• W1995664887 hasConcept C2776694085 @default.
• W1995664887 hasConcept C2777395788 @default.
• W1995664887 hasConcept C2780427987 @default.
• W1995664887 hasConcept C2780439572 @default.
• W1995664887 hasConcept C29456083 @default.
• W1995664887 hasConcept C44249647 @default.
• W1995664887 hasConcept C530470458 @default.
• W1995664887 hasConcept C71924100 @default.

• next