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- W1995675291 abstract "Abstract 4-Alkyl-2,6,7-trioxa-1-phosphabicyclo [2,2,2] octanes are weak competitive inhibitors of the high- K m form of cyclic adenosine 3′,5′-monophosphate phosphodiesterase (PDE) and non-competitive inhibitors of the low- K m form enzyme. The possibility that inhibition of the low- K m form enzyme by the bicyclic organo-phosphates may contribute to their toxic action is discussed. The compounds do not affect the binding of adenosine 3′,5′-monophosphate (cyclic AMP) with specific binding proteins, and are unlikely to have any effect on cyclic AMP receptors." @default.
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- W1995675291 date "1977-05-01" @default.
- W1995675291 modified "2023-09-28" @default.
- W1995675291 title "The interaction of 4-alkyl derivatives of 2,6,7-trioxa-1-phosphabicyclo [2,2,2] octanes with cyclic adenosine 3′,5′-monophosphate phosphodiesterase, and with cyclic adenosine 3′,5′-monophosphate binding proteins" @default.
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- W1995675291 doi "https://doi.org/10.1016/0006-2952(77)90405-1" @default.
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