Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995688061> ?p ?o ?g. }
- W1995688061 endingPage "592" @default.
- W1995688061 startingPage "585" @default.
- W1995688061 abstract "Monolayer cultures of lapine articular chondrocytes were transduced with first-generation adenoviral vectors carrying lacZ or transforming growth factor β1 genes under the transcriptional control of the human cytomegalovirus early promoter. High concentrations of transforming growth factor β1 were produced by chondrocytes following transfer of the transforming growth factor β1 gene but not the lacZ gene. Transduced chondrocytes responded to the elevated endogenous production of transforming growth factor β1 by increasing their synthesis of proteoglycan, collagen, and noncollagenous proteins in a dose-dependent fashion. The increases in collagen synthesis were not accompanied by alterations in the collagen phenotype; type-II collagen remained the predominant collagen. Transforming growth factor β1 could not, however, rescue the collagen phenotype of cells that had undergone phenotypic modulation as a result of serial passaging. These data demonstrate that chondrocytes can be genetically manipulated to produce and respond to the potentially therapeutic cytokine transforming growth factor β1. This technology has a number of experimental and therapeutic applications, including those related to the study and treatment of arthritis and cartilage repair." @default.
- W1995688061 created "2016-06-24" @default.
- W1995688061 creator A5010640380 @default.
- W1995688061 creator A5011034452 @default.
- W1995688061 creator A5026436970 @default.
- W1995688061 creator A5029426261 @default.
- W1995688061 creator A5040467127 @default.
- W1995688061 creator A5063630725 @default.
- W1995688061 creator A5066270370 @default.
- W1995688061 creator A5085719741 @default.
- W1995688061 date "2000-07-01" @default.
- W1995688061 modified "2023-10-09" @default.
- W1995688061 title "Increased matrix synthesis following adenoviral transfer of a transforming growth factor ?1 gene into articular chondrocytes" @default.
- W1995688061 cites W123183995 @default.
- W1995688061 cites W1531925192 @default.
- W1995688061 cites W1582355914 @default.
- W1995688061 cites W1674231565 @default.
- W1995688061 cites W1974957510 @default.
- W1995688061 cites W1984273224 @default.
- W1995688061 cites W1988592246 @default.
- W1995688061 cites W1990856586 @default.
- W1995688061 cites W1991040567 @default.
- W1995688061 cites W1994600856 @default.
- W1995688061 cites W2023037291 @default.
- W1995688061 cites W2032352420 @default.
- W1995688061 cites W2045003319 @default.
- W1995688061 cites W2049382908 @default.
- W1995688061 cites W2050206288 @default.
- W1995688061 cites W2065306872 @default.
- W1995688061 cites W2082317371 @default.
- W1995688061 cites W2094064497 @default.
- W1995688061 cites W2100562749 @default.
- W1995688061 cites W2116441979 @default.
- W1995688061 cites W2116947669 @default.
- W1995688061 cites W2118927304 @default.
- W1995688061 cites W2130535740 @default.
- W1995688061 cites W2133192455 @default.
- W1995688061 cites W2144714494 @default.
- W1995688061 cites W2167587798 @default.
- W1995688061 cites W2208635708 @default.
- W1995688061 cites W2255337241 @default.
- W1995688061 cites W2267601869 @default.
- W1995688061 doi "https://doi.org/10.1002/jor.1100180411" @default.
- W1995688061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11052495" @default.
- W1995688061 hasPublicationYear "2000" @default.
- W1995688061 type Work @default.
- W1995688061 sameAs 1995688061 @default.
- W1995688061 citedByCount "108" @default.
- W1995688061 countsByYear W19956880612012 @default.
- W1995688061 countsByYear W19956880612013 @default.
- W1995688061 countsByYear W19956880612014 @default.
- W1995688061 countsByYear W19956880612015 @default.
- W1995688061 countsByYear W19956880612017 @default.
- W1995688061 countsByYear W19956880612018 @default.
- W1995688061 countsByYear W19956880612019 @default.
- W1995688061 countsByYear W19956880612021 @default.
- W1995688061 countsByYear W19956880612022 @default.
- W1995688061 crossrefType "journal-article" @default.
- W1995688061 hasAuthorship W1995688061A5010640380 @default.
- W1995688061 hasAuthorship W1995688061A5011034452 @default.
- W1995688061 hasAuthorship W1995688061A5026436970 @default.
- W1995688061 hasAuthorship W1995688061A5029426261 @default.
- W1995688061 hasAuthorship W1995688061A5040467127 @default.
- W1995688061 hasAuthorship W1995688061A5063630725 @default.
- W1995688061 hasAuthorship W1995688061A5066270370 @default.
- W1995688061 hasAuthorship W1995688061A5085719741 @default.
- W1995688061 hasConcept C104317684 @default.
- W1995688061 hasConcept C105702510 @default.
- W1995688061 hasConcept C111599444 @default.
- W1995688061 hasConcept C118131993 @default.
- W1995688061 hasConcept C127716648 @default.
- W1995688061 hasConcept C153911025 @default.
- W1995688061 hasConcept C170493617 @default.
- W1995688061 hasConcept C185592680 @default.
- W1995688061 hasConcept C189165786 @default.
- W1995688061 hasConcept C203014093 @default.
- W1995688061 hasConcept C2775960820 @default.
- W1995688061 hasConcept C2778229498 @default.
- W1995688061 hasConcept C2779335624 @default.
- W1995688061 hasConcept C2780550940 @default.
- W1995688061 hasConcept C2781013607 @default.
- W1995688061 hasConcept C32470452 @default.
- W1995688061 hasConcept C40767141 @default.
- W1995688061 hasConcept C502942594 @default.
- W1995688061 hasConcept C55493867 @default.
- W1995688061 hasConcept C86803240 @default.
- W1995688061 hasConcept C95444343 @default.
- W1995688061 hasConceptScore W1995688061C104317684 @default.
- W1995688061 hasConceptScore W1995688061C105702510 @default.
- W1995688061 hasConceptScore W1995688061C111599444 @default.
- W1995688061 hasConceptScore W1995688061C118131993 @default.
- W1995688061 hasConceptScore W1995688061C127716648 @default.
- W1995688061 hasConceptScore W1995688061C153911025 @default.
- W1995688061 hasConceptScore W1995688061C170493617 @default.
- W1995688061 hasConceptScore W1995688061C185592680 @default.
- W1995688061 hasConceptScore W1995688061C189165786 @default.
- W1995688061 hasConceptScore W1995688061C203014093 @default.
- W1995688061 hasConceptScore W1995688061C2775960820 @default.