FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995692207> ?p ?o ?g. }

• W1995692207 abstract "Oral administration of pH buffers can reduce the development of spontaneous and experimental metastases in mice, and has been proposed in clinical trials. Effectiveness of buffer therapy is likely to be affected by diet, which could contribute or interfere with the therapeutic alkalinizing effect. Little data on food pH buffering capacity was available. This study evaluated the pH and buffering capacity of different foods to guide prospective trials and test the effect of the same buffer (lysine) at two different ionization states. Food groups were derived from the Harvard Food Frequency Questionnaire. Foods were blended and pH titrated with acid from initial pH values until 4.0 to determine buffering score, in mmol H+/pH unit. A buffering score was derived as the mEq H+ consumed per serving size to lower from initial to a pH 4.0, the postprandial pH of the distal duodenum. To differentiate buffering effect from any metabolic byproduct effects, we compared the effects of oral lysine buffers prepared at either pH 10.0 or 8.4, which contain 2 and 1 free base amines, respectively. The effect of these on experimental metastases formation in mice following tail vein injection of PC-3M prostate cancer cells were monitored with in vivo bioluminescence. Carbohydrates and dairy products' buffering score varied between 0.5 and 19. Fruits and vegetables showed a low to zero buffering score. The score of meats varied between 6 and 22. Wine and juices had negative scores. Among supplements, sodium bicarbonate and Tums® had the highest buffering capacities, with scores of 11 and 20 per serving size, respectively. The de-buffered lysine had a less pronounced effect of prevention of metastases compared to lysine at pH 10. This study has demonstrated the anti-cancer effects of buffer therapy and suggests foods that can contribute to or compete with this approach to manage cancer." @default.
• W1995692207 created "2016-06-24" @default.
• W1995692207 creator A5009746616 @default.
• W1995692207 creator A5026076619 @default.
• W1995692207 creator A5032533490 @default.
• W1995692207 creator A5048560817 @default.
• W1995692207 creator A5049527754 @default.
• W1995692207 creator A5086011649 @default.
• W1995692207 creator A5090472542 @default.
• W1995692207 creator A5091087343 @default.
• W1995692207 date "2012-01-01" @default.
• W1995692207 modified "2023-10-18" @default.
• W1995692207 title "Buffer Therapy for Cancer" @default.
• W1995692207 cites W1479934248 @default.
• W1995692207 cites W1513692286 @default.
• W1995692207 cites W1962707246 @default.
• W1995692207 cites W1966671206 @default.
• W1995692207 cites W1976383678 @default.
• W1995692207 cites W1976890785 @default.
• W1995692207 cites W1979762980 @default.
• W1995692207 cites W1980235160 @default.
• W1995692207 cites W1983675615 @default.
• W1995692207 cites W1986511378 @default.
• W1995692207 cites W1986553386 @default.
• W1995692207 cites W1990295156 @default.
• W1995692207 cites W1998166655 @default.
• W1995692207 cites W2014807218 @default.
• W1995692207 cites W2037358266 @default.
• W1995692207 cites W2039303091 @default.
• W1995692207 cites W2039444927 @default.
• W1995692207 cites W2043293560 @default.
• W1995692207 cites W2051708290 @default.
• W1995692207 cites W2064102283 @default.
• W1995692207 cites W2074315257 @default.
• W1995692207 cites W2083373186 @default.
• W1995692207 cites W2099334532 @default.
• W1995692207 cites W2102322990 @default.
• W1995692207 cites W2113995990 @default.
• W1995692207 cites W2115909828 @default.
• W1995692207 cites W2117692326 @default.
• W1995692207 cites W2118604693 @default.
• W1995692207 cites W2122061166 @default.
• W1995692207 cites W2126313830 @default.
• W1995692207 cites W2127886703 @default.
• W1995692207 cites W2137629661 @default.
• W1995692207 cites W2143765685 @default.
• W1995692207 cites W2156687584 @default.
• W1995692207 cites W2157168593 @default.
• W1995692207 cites W2159194061 @default.
• W1995692207 cites W2164547751 @default.
• W1995692207 cites W2169672839 @default.
• W1995692207 cites W2171613038 @default.
• W1995692207 cites W2239061749 @default.
• W1995692207 cites W2400743453 @default.
• W1995692207 cites W2977996852 @default.
• W1995692207 cites W64034540 @default.
• W1995692207 doi "https://doi.org/10.4172/2155-9600.s2-006" @default.
• W1995692207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3872072" @default.
• W1995692207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24371544" @default.
• W1995692207 hasPublicationYear "2012" @default.
• W1995692207 type Work @default.
• W1995692207 sameAs 1995692207 @default.
• W1995692207 citedByCount "15" @default.
• W1995692207 countsByYear W19956922072014 @default.
• W1995692207 countsByYear W19956922072015 @default.
• W1995692207 countsByYear W19956922072016 @default.
• W1995692207 countsByYear W19956922072018 @default.
• W1995692207 countsByYear W19956922072021 @default.
• W1995692207 countsByYear W19956922072022 @default.
• W1995692207 countsByYear W19956922072023 @default.
• W1995692207 crossrefType "journal-article" @default.
• W1995692207 hasAuthorship W1995692207A5009746616 @default.
• W1995692207 hasAuthorship W1995692207A5026076619 @default.
• W1995692207 hasAuthorship W1995692207A5032533490 @default.
• W1995692207 hasAuthorship W1995692207A5048560817 @default.
• W1995692207 hasAuthorship W1995692207A5049527754 @default.
• W1995692207 hasAuthorship W1995692207A5086011649 @default.
• W1995692207 hasAuthorship W1995692207A5090472542 @default.
• W1995692207 hasAuthorship W1995692207A5091087343 @default.
• W1995692207 hasConcept C126322002 @default.
• W1995692207 hasConcept C147789679 @default.
• W1995692207 hasConcept C150903083 @default.
• W1995692207 hasConcept C185592680 @default.
• W1995692207 hasConcept C207001950 @default.
• W1995692207 hasConcept C2776420369 @default.
• W1995692207 hasConcept C2778199505 @default.
• W1995692207 hasConcept C2779306644 @default.
• W1995692207 hasConcept C2781112554 @default.
• W1995692207 hasConcept C31903555 @default.
• W1995692207 hasConcept C71924100 @default.
• W1995692207 hasConcept C86803240 @default.
• W1995692207 hasConceptScore W1995692207C126322002 @default.
• W1995692207 hasConceptScore W1995692207C147789679 @default.
• W1995692207 hasConceptScore W1995692207C150903083 @default.
• W1995692207 hasConceptScore W1995692207C185592680 @default.
• W1995692207 hasConceptScore W1995692207C207001950 @default.
• W1995692207 hasConceptScore W1995692207C2776420369 @default.
• W1995692207 hasConceptScore W1995692207C2778199505 @default.
• W1995692207 hasConceptScore W1995692207C2779306644 @default.
• W1995692207 hasConceptScore W1995692207C2781112554 @default.

• next