Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995700564> ?p ?o ?g. }
- W1995700564 endingPage "668" @default.
- W1995700564 startingPage "662" @default.
- W1995700564 abstract "Thromboxane synthase (TXAS) is an enzyme that catalyzes the synthesis of thromboxane A(2) (TXA(2)). Overexpression of TXAS is associated with a variety of vascular diseases. Recently, we reported that visfatin, a novel adipokine, exhibits angiogenic actions. In this study, we showed that visfatin increased mRNA and protein levels of TXAS and stimulated TXA(2) biosynthesis in vascular endothelial cells. In addition, visfatin induced the expression and secretion of interleukin-8 (IL-8), which is blocked by a TXAS inhibitor and by the transfection of siRNA specific for TXAS. Furthermore, the inhibition of TXAS activity and blockade of the IL-8 receptor attenuated visfatin-induced endothelial angiogenesis. Together, these results showed that visfatin promoted IL-8 production by upregulation of TXAS, leading to angiogenic activation in endothelial cells." @default.
- W1995700564 created "2016-06-24" @default.
- W1995700564 creator A5003507095 @default.
- W1995700564 creator A5008324355 @default.
- W1995700564 creator A5008359939 @default.
- W1995700564 creator A5015305100 @default.
- W1995700564 creator A5021061988 @default.
- W1995700564 creator A5061463295 @default.
- W1995700564 creator A5064866127 @default.
- W1995700564 creator A5076771471 @default.
- W1995700564 creator A5083514038 @default.
- W1995700564 date "2012-02-01" @default.
- W1995700564 modified "2023-09-27" @default.
- W1995700564 title "Upregulation of thromboxane synthase mediates visfatin-induced interleukin-8 expression and angiogenic activity in endothelial cells" @default.
- W1995700564 cites W1932093217 @default.
- W1995700564 cites W1970981593 @default.
- W1995700564 cites W1976739913 @default.
- W1995700564 cites W1989922266 @default.
- W1995700564 cites W1992634781 @default.
- W1995700564 cites W1995827857 @default.
- W1995700564 cites W2002354023 @default.
- W1995700564 cites W2002811789 @default.
- W1995700564 cites W2008736982 @default.
- W1995700564 cites W2021246656 @default.
- W1995700564 cites W2025750169 @default.
- W1995700564 cites W2030322570 @default.
- W1995700564 cites W2044378325 @default.
- W1995700564 cites W2044982247 @default.
- W1995700564 cites W2056964156 @default.
- W1995700564 cites W2067290049 @default.
- W1995700564 cites W2067477154 @default.
- W1995700564 cites W2067589527 @default.
- W1995700564 cites W2073455500 @default.
- W1995700564 cites W2086176357 @default.
- W1995700564 cites W2092296830 @default.
- W1995700564 cites W2094117056 @default.
- W1995700564 cites W2110420148 @default.
- W1995700564 cites W2111334331 @default.
- W1995700564 cites W2114357761 @default.
- W1995700564 cites W2115199319 @default.
- W1995700564 cites W2117361450 @default.
- W1995700564 cites W2118450502 @default.
- W1995700564 cites W2121035292 @default.
- W1995700564 cites W2131253478 @default.
- W1995700564 cites W2132000514 @default.
- W1995700564 cites W2138126364 @default.
- W1995700564 cites W2157603347 @default.
- W1995700564 cites W2323643327 @default.
- W1995700564 cites W2592591018 @default.
- W1995700564 cites W4362209267 @default.
- W1995700564 doi "https://doi.org/10.1016/j.bbrc.2012.01.072" @default.
- W1995700564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22293189" @default.
- W1995700564 hasPublicationYear "2012" @default.
- W1995700564 type Work @default.
- W1995700564 sameAs 1995700564 @default.
- W1995700564 citedByCount "18" @default.
- W1995700564 countsByYear W19957005642013 @default.
- W1995700564 countsByYear W19957005642015 @default.
- W1995700564 countsByYear W19957005642016 @default.
- W1995700564 countsByYear W19957005642017 @default.
- W1995700564 countsByYear W19957005642019 @default.
- W1995700564 countsByYear W19957005642020 @default.
- W1995700564 countsByYear W19957005642021 @default.
- W1995700564 countsByYear W19957005642022 @default.
- W1995700564 crossrefType "journal-article" @default.
- W1995700564 hasAuthorship W1995700564A5003507095 @default.
- W1995700564 hasAuthorship W1995700564A5008324355 @default.
- W1995700564 hasAuthorship W1995700564A5008359939 @default.
- W1995700564 hasAuthorship W1995700564A5015305100 @default.
- W1995700564 hasAuthorship W1995700564A5021061988 @default.
- W1995700564 hasAuthorship W1995700564A5061463295 @default.
- W1995700564 hasAuthorship W1995700564A5064866127 @default.
- W1995700564 hasAuthorship W1995700564A5076771471 @default.
- W1995700564 hasAuthorship W1995700564A5083514038 @default.
- W1995700564 hasConcept C104317684 @default.
- W1995700564 hasConcept C11988809 @default.
- W1995700564 hasConcept C126322002 @default.
- W1995700564 hasConcept C127561419 @default.
- W1995700564 hasConcept C134018914 @default.
- W1995700564 hasConcept C170493617 @default.
- W1995700564 hasConcept C173202427 @default.
- W1995700564 hasConcept C185592680 @default.
- W1995700564 hasConcept C2776785769 @default.
- W1995700564 hasConcept C2778690821 @default.
- W1995700564 hasConcept C2780394083 @default.
- W1995700564 hasConcept C2781024287 @default.
- W1995700564 hasConcept C2781080829 @default.
- W1995700564 hasConcept C55493867 @default.
- W1995700564 hasConcept C71924100 @default.
- W1995700564 hasConcept C86803240 @default.
- W1995700564 hasConcept C89560881 @default.
- W1995700564 hasConcept C98274493 @default.
- W1995700564 hasConceptScore W1995700564C104317684 @default.
- W1995700564 hasConceptScore W1995700564C11988809 @default.
- W1995700564 hasConceptScore W1995700564C126322002 @default.
- W1995700564 hasConceptScore W1995700564C127561419 @default.
- W1995700564 hasConceptScore W1995700564C134018914 @default.
- W1995700564 hasConceptScore W1995700564C170493617 @default.