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- W1995707767 abstract "Toll-like receptor 7 (TLR7) and TLR9 sense viral nucleic acids and induce type I IFN production, which must be properly controlled to avoid autoimmune diseases. Here, we report the negative regulation of TLR7/9-mediated type I IFN production by TRIM35. TRIM35 expression is induced by TLR7/9 stimulation and then interacts with IRF7, which is the master regulator of type I IFN response. Furthermore, TRIM35 promotes the K48-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway. Therefore, TRIM35 is a negative feedback regulator of TLR7/9-mediated type I IFN production due to its ability to suppress the stability of IRF7." @default.
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- W1995707767 date "2015-04-20" @default.
- W1995707767 modified "2023-10-17" @default.
- W1995707767 title "TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7" @default.
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- W1995707767 doi "https://doi.org/10.1016/j.febslet.2015.04.019" @default.
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