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• W1995713013 abstract "1. The mechanism of placental transport of Na was studied in guinea-pigs in placentae with intact umbilical blood circulation or in the preparation of the placenta perfused in situ. 2. A constant level of 22Na was maintained in maternal plasma for 60 min, and from the quantity of 22Na recovered from the foetus at the end of this period the influx of Na from mother to foetus was calculated. Ligation of the omphalomesenteric vessels (supplying the everted yolk sac with blood) had no effect on the influx, the corresponding values of influx in the control and treated foetuses being 0-235 +/- 0-020 and 0-247 +/- 0-029 micron-mole/min. g foetal weight (n = 6, the limits are S.E. of mean). The specific activity of Na in amniotic fluid was below that of the maternal or foetal plasma Na by two orders of magnitude. These observations indicate that the extraplacental transport of Na into the foetus is negligibly low. 3. The electrical potential difference (p.d.) and unidirectional fluxes of Na across the placenta perfused in situ were measured by means of 22Na and 24Na administered to the opposite sides of the placental barrier. The fluxes varied with the weight of the foetuses whose placentae were perfused. The flux from the maternal to the foetal side was 0-270 +/- 0-017 micronmole/min.g foetal weight, the flux from the foetal to the maternal side was 0-340 +/- 0-018 micronmole/min.g foetal weight (n = 38). The corresponding p.d. was - 20-7 +/- 1-2 mV (foetal side negative). 4. The active component of Na transport across the placenta was calculated from the unidirectional fluxes and the p.d. The active transport was directed from the foetal to the maternal side, and its rate was 0-211 +/- 0-015 micronmole/min.g foetal weight (n = 38). During perfusion of the placenta with KCN (10(-3) M) the active transport decreased by approximately one third. 5. The flux of Na from the foetal to the maternal side of the perfused placenta was higher than the flux from the maternal to the foetal side. A similar asymmetry of Na fluxes was observed in the non-perfused placenta, the flux from mother to foetus being 0-180 +/- 0-013 micronmole/min.g foetal weight and the flux from foetus to mother 0-235 +/- 0-024 micronmole/min.g foetal weight (n = 12). This indicates that the asymmetry of Na fluxes is caused by the anaesthesia and/or by the trauma of the operation rather than by the perfusion of the placenta. 6. The permeabilities of the perfused placenta to Na and sucrose measured simultaneously from the maternal to the foetal side were 0-0767 +/- 0-0183 and 0-324 +/- 0-0094 cm3/min (n = 7y, respectively. The permeability values bear the same relation to each other as the respective coefficients of free diffusion in water, suggesting that the passive transport of Na across the placenta takes place as simple diffusion through wide aqueous channels. 6..." @default.
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• W1995713013 date "1977-03-01" @default.
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• W1995713013 title "Placental transport of sodium in the guinea-pig." @default.
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• W1995713013 doi "https://doi.org/10.1113/jphysiol.1977.sp011738" @default.
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