Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995717154> ?p ?o ?g. }
- W1995717154 endingPage "2546" @default.
- W1995717154 startingPage "2541" @default.
- W1995717154 abstract "The difficulty of analyzing higher order RNA structure, especially for folding intermediates and for RNAs whose functions require domains that are conformationally flexible, emphasizes the need for new approaches for modeling RNA tertiary structure accurately. Here, we report a concise approach that makes use of facile RNA structure probing experiments that are then interpreted using a computational algorithm, carefully tailored to optimize both the resolution and refinement speed for the resulting structures, without requiring user intervention. The RNA secondary structure is first established using SHAPE chemistry. We then use a sequence-directed cleavage agent, which can be placed arbitrarily in many helical motifs, to obtain high quality inter-residue distances. We interpret this in-solution chemical information using a fast, coarse grained, discrete molecular dynamics engine in which each RNA nucleotide is represented by pseudoatoms for the phosphate, ribose, and nucleobase groups. By this approach, we refine base paired positions in yeast tRNA(Asp) to 4 A rmsd without any preexisting information or assumptions about secondary or tertiary structures. This blended experimental and computational approach has the potential to yield native-like models for the diverse universe of functionally important RNAs whose structures cannot be characterized by conventional structural methods." @default.
- W1995717154 created "2016-06-24" @default.
- W1995717154 creator A5002304675 @default.
- W1995717154 creator A5013737207 @default.
- W1995717154 creator A5019911627 @default.
- W1995717154 creator A5033490428 @default.
- W1995717154 creator A5050389355 @default.
- W1995717154 date "2009-02-04" @default.
- W1995717154 modified "2023-10-05" @default.
- W1995717154 title "Native-like RNA Tertiary Structures Using a Sequence-Encoded Cleavage Agent and Refinement by Discrete Molecular Dynamics" @default.
- W1995717154 cites W1661638276 @default.
- W1995717154 cites W175262619 @default.
- W1995717154 cites W1966920734 @default.
- W1995717154 cites W1970880248 @default.
- W1995717154 cites W1972533328 @default.
- W1995717154 cites W1976624218 @default.
- W1995717154 cites W1985281561 @default.
- W1995717154 cites W1988409793 @default.
- W1995717154 cites W1992089557 @default.
- W1995717154 cites W2003049655 @default.
- W1995717154 cites W2003122343 @default.
- W1995717154 cites W2004945910 @default.
- W1995717154 cites W2017838368 @default.
- W1995717154 cites W2027139827 @default.
- W1995717154 cites W2044338343 @default.
- W1995717154 cites W2051188149 @default.
- W1995717154 cites W2064066892 @default.
- W1995717154 cites W2065039265 @default.
- W1995717154 cites W2069983479 @default.
- W1995717154 cites W2071883352 @default.
- W1995717154 cites W2085272777 @default.
- W1995717154 cites W2091502996 @default.
- W1995717154 cites W2098070884 @default.
- W1995717154 cites W2106434056 @default.
- W1995717154 cites W2118780761 @default.
- W1995717154 cites W2120014697 @default.
- W1995717154 cites W2120974004 @default.
- W1995717154 cites W2128143642 @default.
- W1995717154 cites W2134036931 @default.
- W1995717154 cites W2151596277 @default.
- W1995717154 cites W2157282617 @default.
- W1995717154 cites W2157467256 @default.
- W1995717154 cites W2165961683 @default.
- W1995717154 doi "https://doi.org/10.1021/ja805460e" @default.
- W1995717154 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2664099" @default.
- W1995717154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19193004" @default.
- W1995717154 hasPublicationYear "2009" @default.
- W1995717154 type Work @default.
- W1995717154 sameAs 1995717154 @default.
- W1995717154 citedByCount "66" @default.
- W1995717154 countsByYear W19957171542012 @default.
- W1995717154 countsByYear W19957171542013 @default.
- W1995717154 countsByYear W19957171542014 @default.
- W1995717154 countsByYear W19957171542015 @default.
- W1995717154 countsByYear W19957171542016 @default.
- W1995717154 countsByYear W19957171542017 @default.
- W1995717154 countsByYear W19957171542018 @default.
- W1995717154 countsByYear W19957171542019 @default.
- W1995717154 countsByYear W19957171542021 @default.
- W1995717154 countsByYear W19957171542022 @default.
- W1995717154 crossrefType "journal-article" @default.
- W1995717154 hasAuthorship W1995717154A5002304675 @default.
- W1995717154 hasAuthorship W1995717154A5013737207 @default.
- W1995717154 hasAuthorship W1995717154A5019911627 @default.
- W1995717154 hasAuthorship W1995717154A5033490428 @default.
- W1995717154 hasAuthorship W1995717154A5050389355 @default.
- W1995717154 hasBestOaLocation W19957171542 @default.
- W1995717154 hasConcept C104317684 @default.
- W1995717154 hasConcept C105130999 @default.
- W1995717154 hasConcept C11413529 @default.
- W1995717154 hasConcept C126142528 @default.
- W1995717154 hasConcept C147597530 @default.
- W1995717154 hasConcept C153957851 @default.
- W1995717154 hasConcept C181199279 @default.
- W1995717154 hasConcept C185581394 @default.
- W1995717154 hasConcept C185592680 @default.
- W1995717154 hasConcept C2778112365 @default.
- W1995717154 hasConcept C2779461342 @default.
- W1995717154 hasConcept C41008148 @default.
- W1995717154 hasConcept C512185932 @default.
- W1995717154 hasConcept C552990157 @default.
- W1995717154 hasConcept C55493867 @default.
- W1995717154 hasConcept C59593255 @default.
- W1995717154 hasConcept C61234307 @default.
- W1995717154 hasConcept C62614982 @default.
- W1995717154 hasConcept C67705224 @default.
- W1995717154 hasConcept C70721500 @default.
- W1995717154 hasConcept C75599170 @default.
- W1995717154 hasConcept C85468374 @default.
- W1995717154 hasConcept C86803240 @default.
- W1995717154 hasConceptScore W1995717154C104317684 @default.
- W1995717154 hasConceptScore W1995717154C105130999 @default.
- W1995717154 hasConceptScore W1995717154C11413529 @default.
- W1995717154 hasConceptScore W1995717154C126142528 @default.
- W1995717154 hasConceptScore W1995717154C147597530 @default.
- W1995717154 hasConceptScore W1995717154C153957851 @default.
- W1995717154 hasConceptScore W1995717154C181199279 @default.
- W1995717154 hasConceptScore W1995717154C185581394 @default.