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• W1995736586 abstract "CD8+ cytotoxic T lymphocytes are critical components of immunity against infectious pathogens, tumours, and in the case of pathogenic autoimmunity, normal self tissues. CD4+ T (TH) cells provide 'help' to CD8+ cytotoxic T lymphocytes during priming by first activating antigen-presenting cells via CD40–CD40L interactions. Here we show that, after immunization with either a noninflammatory, nonreplicating antigen or an overtly inflammatory replicating antigen, CD8+ cytotoxic T lymphocytes prevented from receiving a signal through CD27 during priming subsequently exhibit a specific defect in their capacity for secondary expansion that can be rescued by the absence of TRAIL. Thus, the 'help message' is transmitted to CD8+ T cells via CD70–CD27 signals, enabling them to undergo secondary expansion and avoid TRAIL-mediated apoptosis on re-stimulation. These findings complete our understanding of the cellular interactions through which TH is provided to CD8+ cytotoxic T lymphocytes during priming. CD8+ memory cytotoxic T lymphocytes need help from CD4+ T cells to undergo secondary expansion but the mechanisms of help are not fully understood. Here, it is shown that, after activation by CD4+ T cells, antigen-presenting cells activate CD8+T cells via the CD70/CD27 co-stimulatory pathway." @default.
• W1995736586 created "2016-06-24" @default.
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• W1995736586 date "2012-07-10" @default.
• W1995736586 modified "2023-10-10" @default.
• W1995736586 title "The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27–CD70 interactions" @default.
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• W1995736586 doi "https://doi.org/10.1038/ncomms1948" @default.
• W1995736586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3606886" @default.
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