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• W1995745962 abstract "Effects of chronic treatment with propranolol or atenolol on stress-induced changes in blood pressure, body weight, and cerebral beta-adrenoceptors in rats were examined and compared with the effects of chronic treatment with prazosin. Immobilization stress (2 h daily for 2 weeks) induced a moderate elevation of blood pressure, loss of body weight gain, and downregulation of cerebral beta-adrenoceptors, but produced no changes in the cerebral alpha 1-adrenoceptors. Chronic administration of propranolol (5 or 50 mg.kg-1), atenolol (5 or 50 mg.kg-1) or prazosin (2 or 20 mg.kg-1) inhibited stress-induced hypertension but did not affect loss of body weight gain. Propranolol increased the density of cerebral beta-adrenoceptors by 77% and reduced the downregulation induced by stress. Atenolol also increased the density of cerebral beta-adrenoceptors by 34% and abolished the stress-induced downregulation in cerebral beta-adrenoceptor density. In contrast, prazosin had no effect on the cerebral beta-adrenoceptors in nonstressed or stressed rats. These results suggest that the antihypertensive action of propranolol and atenolol may be partly associated with the inhibition of stress-activated central beta-adrenoceptor transmission." @default.
• W1995745962 created "2016-06-24" @default.
• W1995745962 creator A5079117338 @default.
• W1995745962 date "1995-02-01" @default.
• W1995745962 modified "2023-09-23" @default.
• W1995745962 title "Effects of propranolol and atenolol on immobilization stress-induced hypertension and down-regulation of central β-adrenoceptors in rats" @default.
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• W1995745962 doi "https://doi.org/10.1016/0091-3057(94)00301-x" @default.
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