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• W1995747659 abstract "To determine B-type natriuretic peptide (BNP) levels in infants and children with acute lung injury (ALI), and to investigate associations between BNP levels and clinical outcome.Prospective observational study.After informed consent, plasma was collected from 48 pediatric patients on day 1 of ALI.Plasma BNP levels were measured by immunoassay on day 1 of ALI in 48 pediatric patients. Associations between BNP levels and outcome were determined.The mean PaO(2)/FiO(2) at the onset of ALI was 155 (+/-74) and BNP values ranged from 5 to 2,060 pg/ml with a mean of 109 (+/-311). BNP levels were inversely correlated with ventilator-free days (Spearman rho -0.30, P = 0.04), and positively correlated with exhaled tidal volume (Spearman rho 0.44, P = 0.02). BNP levels were higher in patients receiving inotropic support (n = 12) than patients not receiving inotropic support (n = 33, P = 0.02). BNP levels were correlated with PRISM III scores (Spearman rho 0.55, P < 0.001) and PELOD scores (Spearman rho 0.4, P = 0.006). Mortality for the cohort was 15%. BNP levels were higher in non-survivors (n = 7) than survivors (n = 41, P = 0.055).BNP levels are elevated in children with ALI/ARDS early in the disease course, and increased levels are associated with worse clinical outcome." @default.
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• W1995747659 date "2009-10-14" @default.
• W1995747659 modified "2023-10-17" @default.
• W1995747659 title "Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury" @default.
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• W1995747659 doi "https://doi.org/10.1002/ppul.21111" @default.
• W1995747659 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4427345" @default.
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