Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995760897> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1995760897 endingPage "74" @default.
- W1995760897 startingPage "68" @default.
- W1995760897 abstract "HO-1-u-1 (Ueda-1) is a human tumor cell line established from human sublingual squamous cell carcinoma. In previous study, HO-1-u-1 cell line was grown on cell culture inserts and utilized as in vitro model for screening sublingual drug delivery. The aim of current study was to further investigate the effects of pH, osmolarity and permeation enhancer, sodium glycodeoxycholate (GDC) on the permeability of three β-blockers with different lipophilicities. The cytotoxicity was evaluated by MTS/PES assay. The permeability studies were carried out using the cell culture model and compared with that obtained from fresh porcine sublingual mucosa. The results showed the enhancement effects caused by pH, osmolarity and GDC were highly lipophilicity-dependent and in the order atenolol > metoprolol > propranolol. The apparent permeability coefficients (Papp) of all the three β-blockers were significantly increased by increasing pH. However, less enhancing effects were observed by non-physiological osmolarity or the presence of GDC in permeability study using both cell culture and porcine sublingual mucosa. The present results suggested that the HO-1-u-1 cell culture model maybe a useful and effective in vitro model for evaluating the enhancement effects and mechanism in sublingual drug delivery." @default.
- W1995760897 created "2016-06-24" @default.
- W1995760897 creator A5022832205 @default.
- W1995760897 creator A5059925734 @default.
- W1995760897 creator A5081004832 @default.
- W1995760897 date "2009-03-31" @default.
- W1995760897 modified "2023-09-26" @default.
- W1995760897 title "HO-1-u-1 model for screening sublingual drug delivery—Influence of pH, osmolarity and permeation enhancer" @default.
- W1995760897 cites W1564906832 @default.
- W1995760897 cites W1966191794 @default.
- W1995760897 cites W1967892728 @default.
- W1995760897 cites W2002497242 @default.
- W1995760897 cites W2037346345 @default.
- W1995760897 cites W2065716288 @default.
- W1995760897 cites W2073672690 @default.
- W1995760897 cites W2080516158 @default.
- W1995760897 cites W2133854477 @default.
- W1995760897 cites W2316599884 @default.
- W1995760897 cites W256510981 @default.
- W1995760897 cites W300980745 @default.
- W1995760897 cites W561558549 @default.
- W1995760897 doi "https://doi.org/10.1016/j.ijpharm.2008.11.010" @default.
- W1995760897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19071203" @default.
- W1995760897 hasPublicationYear "2009" @default.
- W1995760897 type Work @default.
- W1995760897 sameAs 1995760897 @default.
- W1995760897 citedByCount "21" @default.
- W1995760897 countsByYear W19957608972013 @default.
- W1995760897 countsByYear W19957608972014 @default.
- W1995760897 countsByYear W19957608972015 @default.
- W1995760897 countsByYear W19957608972016 @default.
- W1995760897 countsByYear W19957608972018 @default.
- W1995760897 countsByYear W19957608972021 @default.
- W1995760897 countsByYear W19957608972023 @default.
- W1995760897 crossrefType "journal-article" @default.
- W1995760897 hasAuthorship W1995760897A5022832205 @default.
- W1995760897 hasAuthorship W1995760897A5059925734 @default.
- W1995760897 hasAuthorship W1995760897A5081004832 @default.
- W1995760897 hasConcept C109316439 @default.
- W1995760897 hasConcept C120882062 @default.
- W1995760897 hasConcept C126322002 @default.
- W1995760897 hasConcept C129900496 @default.
- W1995760897 hasConcept C185592680 @default.
- W1995760897 hasConcept C201399114 @default.
- W1995760897 hasConcept C202751555 @default.
- W1995760897 hasConcept C2776525901 @default.
- W1995760897 hasConcept C41625074 @default.
- W1995760897 hasConcept C43617362 @default.
- W1995760897 hasConcept C50670333 @default.
- W1995760897 hasConcept C54355233 @default.
- W1995760897 hasConcept C55493867 @default.
- W1995760897 hasConcept C71924100 @default.
- W1995760897 hasConcept C81885089 @default.
- W1995760897 hasConcept C84393581 @default.
- W1995760897 hasConcept C86803240 @default.
- W1995760897 hasConcept C98274493 @default.
- W1995760897 hasConceptScore W1995760897C109316439 @default.
- W1995760897 hasConceptScore W1995760897C120882062 @default.
- W1995760897 hasConceptScore W1995760897C126322002 @default.
- W1995760897 hasConceptScore W1995760897C129900496 @default.
- W1995760897 hasConceptScore W1995760897C185592680 @default.
- W1995760897 hasConceptScore W1995760897C201399114 @default.
- W1995760897 hasConceptScore W1995760897C202751555 @default.
- W1995760897 hasConceptScore W1995760897C2776525901 @default.
- W1995760897 hasConceptScore W1995760897C41625074 @default.
- W1995760897 hasConceptScore W1995760897C43617362 @default.
- W1995760897 hasConceptScore W1995760897C50670333 @default.
- W1995760897 hasConceptScore W1995760897C54355233 @default.
- W1995760897 hasConceptScore W1995760897C55493867 @default.
- W1995760897 hasConceptScore W1995760897C71924100 @default.
- W1995760897 hasConceptScore W1995760897C81885089 @default.
- W1995760897 hasConceptScore W1995760897C84393581 @default.
- W1995760897 hasConceptScore W1995760897C86803240 @default.
- W1995760897 hasConceptScore W1995760897C98274493 @default.
- W1995760897 hasIssue "1-2" @default.
- W1995760897 hasLocation W19957608971 @default.
- W1995760897 hasLocation W19957608972 @default.
- W1995760897 hasOpenAccess W1995760897 @default.
- W1995760897 hasPrimaryLocation W19957608971 @default.
- W1995760897 hasRelatedWork W1544357884 @default.
- W1995760897 hasRelatedWork W1999272804 @default.
- W1995760897 hasRelatedWork W2047861063 @default.
- W1995760897 hasRelatedWork W2052460192 @default.
- W1995760897 hasRelatedWork W2120329549 @default.
- W1995760897 hasRelatedWork W2151681059 @default.
- W1995760897 hasRelatedWork W2157493302 @default.
- W1995760897 hasRelatedWork W2416964709 @default.
- W1995760897 hasRelatedWork W2464301138 @default.
- W1995760897 hasRelatedWork W2520280529 @default.
- W1995760897 hasVolume "370" @default.
- W1995760897 isParatext "false" @default.
- W1995760897 isRetracted "false" @default.
- W1995760897 magId "1995760897" @default.
- W1995760897 workType "article" @default.