FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995764114> ?p ?o ?g. }

• W1995764114 endingPage "313" @default.
• W1995764114 startingPage "300" @default.
• W1995764114 abstract "We analysed the effects of all-trans retinoic acid (ATRA) on proliferation and changes in the global proteome of the nullipotent human embryonal carcinoma cell line 2102Ep and the pluripotent cell line NTERA2 cl.D1 (NT2). Differentially expressed proteins were assessed by 2D-PAGE and mass spectrometry, followed by verification and analysis of protein modifications of proteins of the retinoid pathway. We established a proteome map of the germ cell tumor (GCT) cell line NT2 showing neuronal differentiation under ATRA treatment for 7days. Using bioinformatic analyses, we identified functional groups of altered proteins and potentially involved pathways, of which changes to the organization of the cytoskeleton and anti-apoptotic effects were the most prominent. Changes observed in the expression of factors involved in the retinoid pathway under ATRA, namely an upregulation of CRBP and CRABP2, were also reflected in GCT tissues of different histologies, providing further insight into factors involved in the differentiation of these pluripotent tumors.Treatment of NT2 germ cell tumor cells with all-trans retinoic acid (ATRA) is a model to investigate differentiation. We analysed differentially expressed proteins by 2D-PAGE and mass spectrometry and provide a proteome map of NT2 cells under 7days of ATRA. By bioinformatic analyses, functional groups of proteins and involved pathways like changes to the cytoskeleton and anti-apoptotic effects were identified. Factors involved in the retinoid pathway, in particular upregulation of CRBP, CRABP1 and CRABP2, also showed differential expression in tumors with different histological subtypes, which provides insight into gene regulation under induced and spontaneous differentiation in germ cell tumors." @default.
• W1995764114 created "2016-06-24" @default.
• W1995764114 creator A5012148121 @default.
• W1995764114 creator A5014887167 @default.
• W1995764114 creator A5015228710 @default.
• W1995764114 creator A5022303020 @default.
• W1995764114 creator A5024657373 @default.
• W1995764114 creator A5032449278 @default.
• W1995764114 creator A5044109674 @default.
• W1995764114 creator A5059042205 @default.
• W1995764114 creator A5064107781 @default.
• W1995764114 creator A5068081109 @default.
• W1995764114 creator A5073247219 @default.
• W1995764114 creator A5078383767 @default.
• W1995764114 date "2014-01-01" @default.
• W1995764114 modified "2023-09-27" @default.
• W1995764114 title "Proteome analysis of the effects of all-trans retinoic acid on human germ cell tumor cell lines" @default.
• W1995764114 cites W1522458653 @default.
• W1995764114 cites W1896246854 @default.
• W1995764114 cites W1935082899 @default.
• W1995764114 cites W1982876440 @default.
• W1995764114 cites W1985213868 @default.
• W1995764114 cites W1989233727 @default.
• W1995764114 cites W2013120348 @default.
• W1995764114 cites W2023624353 @default.
• W1995764114 cites W2023914797 @default.
• W1995764114 cites W2026029194 @default.
• W1995764114 cites W2026084160 @default.
• W1995764114 cites W2033469836 @default.
• W1995764114 cites W2034044892 @default.
• W1995764114 cites W2036259410 @default.
• W1995764114 cites W2041813580 @default.
• W1995764114 cites W2045889399 @default.
• W1995764114 cites W2065474435 @default.
• W1995764114 cites W2076534093 @default.
• W1995764114 cites W2081013427 @default.
• W1995764114 cites W2092852306 @default.
• W1995764114 cites W2094237750 @default.
• W1995764114 cites W2102594480 @default.
• W1995764114 cites W2110178099 @default.
• W1995764114 cites W2116443392 @default.
• W1995764114 cites W2122683221 @default.
• W1995764114 cites W2138524543 @default.
• W1995764114 cites W2163112976 @default.
• W1995764114 cites W2170191832 @default.
• W1995764114 cites W2220131022 @default.
• W1995764114 cites W2331397206 @default.
• W1995764114 cites W4293247451 @default.
• W1995764114 cites W1967982416 @default.
• W1995764114 doi "https://doi.org/10.1016/j.jprot.2013.11.010" @default.
• W1995764114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24269351" @default.
• W1995764114 hasPublicationYear "2014" @default.
• W1995764114 type Work @default.
• W1995764114 sameAs 1995764114 @default.
• W1995764114 citedByCount "13" @default.
• W1995764114 countsByYear W19957641142014 @default.
• W1995764114 countsByYear W19957641142015 @default.
• W1995764114 countsByYear W19957641142016 @default.
• W1995764114 countsByYear W19957641142017 @default.
• W1995764114 countsByYear W19957641142018 @default.
• W1995764114 countsByYear W19957641142019 @default.
• W1995764114 countsByYear W19957641142020 @default.
• W1995764114 countsByYear W19957641142021 @default.
• W1995764114 countsByYear W19957641142022 @default.
• W1995764114 countsByYear W19957641142023 @default.
• W1995764114 crossrefType "journal-article" @default.
• W1995764114 hasAuthorship W1995764114A5012148121 @default.
• W1995764114 hasAuthorship W1995764114A5014887167 @default.
• W1995764114 hasAuthorship W1995764114A5015228710 @default.
• W1995764114 hasAuthorship W1995764114A5022303020 @default.
• W1995764114 hasAuthorship W1995764114A5024657373 @default.
• W1995764114 hasAuthorship W1995764114A5032449278 @default.
• W1995764114 hasAuthorship W1995764114A5044109674 @default.
• W1995764114 hasAuthorship W1995764114A5059042205 @default.
• W1995764114 hasAuthorship W1995764114A5064107781 @default.
• W1995764114 hasAuthorship W1995764114A5068081109 @default.
• W1995764114 hasAuthorship W1995764114A5073247219 @default.
• W1995764114 hasAuthorship W1995764114A5078383767 @default.
• W1995764114 hasConcept C104317684 @default.
• W1995764114 hasConcept C104397665 @default.
• W1995764114 hasConcept C127561419 @default.
• W1995764114 hasConcept C148738053 @default.
• W1995764114 hasConcept C1491633281 @default.
• W1995764114 hasConcept C153911025 @default.
• W1995764114 hasConcept C20875687 @default.
• W1995764114 hasConcept C26805974 @default.
• W1995764114 hasConcept C2775954498 @default.
• W1995764114 hasConcept C2780327976 @default.
• W1995764114 hasConcept C2781121885 @default.
• W1995764114 hasConcept C46111723 @default.
• W1995764114 hasConcept C54355233 @default.
• W1995764114 hasConcept C55493867 @default.
• W1995764114 hasConcept C62112901 @default.
• W1995764114 hasConcept C81885089 @default.
• W1995764114 hasConcept C86803240 @default.
• W1995764114 hasConcept C95444343 @default.
• W1995764114 hasConceptScore W1995764114C104317684 @default.
• W1995764114 hasConceptScore W1995764114C104397665 @default.

• next