FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995771017> ?p ?o ?g. }

• W1995771017 endingPage "2333" @default.
• W1995771017 startingPage "2322" @default.
• W1995771017 abstract "p62 is a multifunctional cytoplasmic protein able to noncovalently bind ubiquitin and several signaling proteins, suggesting a regulatory role connected to the ubiquitin-proteasome pathway. No studies to date have linked p62 protein expression with pathological states. Here we demonstrate the overabundance of p62 protein in malignant breast tissue relative to normal breast tissue. The proteasome inhibitor PSI increased p62 mRNA and protein; however, PSI treatment of breast epithelial cells transfected with the p62 promoter did not affect promoter activity. High levels of prostate-derived Ets factor (PDEF) mRNA have been identified in breast cancer compared to normal breast. Only the PSA and maspin promoters have been identified as targets of this transcription factor. Here we show that PDEF stimulates the p62 promoter through at least two sites, and likely acts as a coactivator. PSI treatment abrogates the PDEF-stimulated increase of p62 promoter activity by 50%. Thus, multiple mechanisms for the induction of p62 exist. We conclude that (1) p62 protein is overexpressed in breast cancer; (2) p62 mRNA and protein increase in response to PSI, with no change of basal promoter activity; (3) PDEF upregulates p62 promoter activity through at least two sites; and (4) PSI downregulates PDEF-induced p62 promoter activation through one of these sites." @default.
• W1995771017 created "2016-06-24" @default.
• W1995771017 creator A5005046358 @default.
• W1995771017 creator A5022307884 @default.
• W1995771017 creator A5056820199 @default.
• W1995771017 creator A5066794569 @default.
• W1995771017 creator A5085294996 @default.
• W1995771017 date "2003-04-17" @default.
• W1995771017 modified "2023-10-05" @default.
• W1995771017 title "p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells" @default.
• W1995771017 cites W147591239 @default.
• W1995771017 cites W1541544453 @default.
• W1995771017 cites W1606273823 @default.
• W1995771017 cites W1967776802 @default.
• W1995771017 cites W1967871528 @default.
• W1995771017 cites W1976067097 @default.
• W1995771017 cites W1976578056 @default.
• W1995771017 cites W1995900367 @default.
• W1995771017 cites W2015432131 @default.
• W1995771017 cites W2021883084 @default.
• W1995771017 cites W2032888222 @default.
• W1995771017 cites W2039137539 @default.
• W1995771017 cites W2039504258 @default.
• W1995771017 cites W2040160673 @default.
• W1995771017 cites W2042290382 @default.
• W1995771017 cites W2048124079 @default.
• W1995771017 cites W2051905656 @default.
• W1995771017 cites W2056031203 @default.
• W1995771017 cites W2057997371 @default.
• W1995771017 cites W2058231034 @default.
• W1995771017 cites W2067530043 @default.
• W1995771017 cites W2070147996 @default.
• W1995771017 cites W2076111240 @default.
• W1995771017 cites W2076712307 @default.
• W1995771017 cites W2078427707 @default.
• W1995771017 cites W2089519022 @default.
• W1995771017 cites W2093227216 @default.
• W1995771017 cites W2098257571 @default.
• W1995771017 cites W2104366204 @default.
• W1995771017 cites W2109959108 @default.
• W1995771017 cites W2118318352 @default.
• W1995771017 cites W2121781216 @default.
• W1995771017 cites W2158325024 @default.
• W1995771017 cites W2163638464 @default.
• W1995771017 cites W2312647513 @default.
• W1995771017 cites W2329048545 @default.
• W1995771017 cites W4246021513 @default.
• W1995771017 cites W4293247451 @default.
• W1995771017 cites W1987935298 @default.
• W1995771017 doi "https://doi.org/10.1038/sj.onc.1206325" @default.
• W1995771017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12700667" @default.
• W1995771017 hasPublicationYear "2003" @default.
• W1995771017 type Work @default.
• W1995771017 sameAs 1995771017 @default.
• W1995771017 citedByCount "161" @default.
• W1995771017 countsByYear W19957710172012 @default.
• W1995771017 countsByYear W19957710172013 @default.
• W1995771017 countsByYear W19957710172014 @default.
• W1995771017 countsByYear W19957710172015 @default.
• W1995771017 countsByYear W19957710172016 @default.
• W1995771017 countsByYear W19957710172017 @default.
• W1995771017 countsByYear W19957710172018 @default.
• W1995771017 countsByYear W19957710172019 @default.
• W1995771017 countsByYear W19957710172020 @default.
• W1995771017 countsByYear W19957710172021 @default.
• W1995771017 countsByYear W19957710172022 @default.
• W1995771017 countsByYear W19957710172023 @default.
• W1995771017 crossrefType "journal-article" @default.
• W1995771017 hasAuthorship W1995771017A5005046358 @default.
• W1995771017 hasAuthorship W1995771017A5022307884 @default.
• W1995771017 hasAuthorship W1995771017A5056820199 @default.
• W1995771017 hasAuthorship W1995771017A5066794569 @default.
• W1995771017 hasAuthorship W1995771017A5085294996 @default.
• W1995771017 hasBestOaLocation W19957710171 @default.
• W1995771017 hasConcept C101762097 @default.
• W1995771017 hasConcept C104317684 @default.
• W1995771017 hasConcept C105580179 @default.
• W1995771017 hasConcept C121608353 @default.
• W1995771017 hasConcept C150194340 @default.
• W1995771017 hasConcept C25602115 @default.
• W1995771017 hasConcept C27740335 @default.
• W1995771017 hasConcept C2778900538 @default.
• W1995771017 hasConcept C2779013556 @default.
• W1995771017 hasConcept C502942594 @default.
• W1995771017 hasConcept C530470458 @default.
• W1995771017 hasConcept C54009773 @default.
• W1995771017 hasConcept C54355233 @default.
• W1995771017 hasConcept C77445288 @default.
• W1995771017 hasConcept C86339819 @default.
• W1995771017 hasConcept C86803240 @default.
• W1995771017 hasConcept C95444343 @default.
• W1995771017 hasConceptScore W1995771017C101762097 @default.
• W1995771017 hasConceptScore W1995771017C104317684 @default.
• W1995771017 hasConceptScore W1995771017C105580179 @default.
• W1995771017 hasConceptScore W1995771017C121608353 @default.
• W1995771017 hasConceptScore W1995771017C150194340 @default.
• W1995771017 hasConceptScore W1995771017C25602115 @default.
• W1995771017 hasConceptScore W1995771017C27740335 @default.

• next