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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995771845> ?p ?o ?g. }

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• W1995771845 abstract "Lengsin (LGS) is an abundant transcript in the human lens, encoding a predicted polypeptide similar to glutamine synthetase (GS). We show that a major alternatively spliced product of LGS codes for a 57kDa polypeptide that assembles into a catalytically inactive dodecamer, cross-reacts with anti-GS antibodies, and is expressed at high levels in transparent, but not cataractous, human lenses. Based on this characteristic oligomeric organization, preferential expression in the transparent lens, and amyloid-beta association previously reported for GS, a potential chaperone-like role of LGS has been investigated. We find that LGS has six binding sites for the hydrophobic surface probe bis-ANS and relieves cellular toxicity caused by amyloid-beta expression in a folding-impaired yeast mutant. While documenting the structural similarity between LGS and prokaryotic GS-I, the data rule out any involvement of lengsin in glutamine biosynthesis and suggest an unrelated role that may be important for lens homeostasis and transparency." @default.
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• W1995771845 date "2006-11-01" @default.
• W1995771845 modified "2023-10-14" @default.
• W1995771845 title "Structural and functional properties of lengsin, a pseudo-glutamine synthetase in the transparent human lens" @default.
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• W1995771845 doi "https://doi.org/10.1016/j.bbrc.2006.09.062" @default.
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