FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995773697> ?p ?o ?g. }

• W1995773697 endingPage "15423" @default.
• W1995773697 startingPage "15418" @default.
• W1995773697 abstract "Human colonic epithelial cell renewal, proliferation, and differentiation are stringently controlled by numerous regulatory pathways. To identify genetic programs of human colonic epithelial cell differentiation in vivo as well as candidate marker genes that define colonic epithelial stem/progenitor cells and the stem cell niche, we applied gene expression analysis of normal human colon tops and basal crypts by using expression microarrays with 30,000 genes. Nine hundred and sixty-nine cDNA clones were found to be differentially expressed between human colon crypts and tops. Pathway analysis revealed the differential expression of genes involved in cell cycle maintenance and apoptosis, as well as genes in bone morphogenetic protein (BMP), Notch, Wnt, EPH, and MYC signaling pathways. BMP antagonists gremlin 1, gremlin 2, and chordin-like 1 were found to be expressed by colon crypts. In situ hybridization and RT-PCR confirmed that these BMP antagonists are expressed by intestinal cryptal myofibroblasts and smooth muscle cells at the colon crypt. In vitro analysis demonstrated that gremlin 1 partially inhibits Caco-2 cell differentiation upon confluence and activates Wnt signaling in normal rat intestinal epithelial cells. Collectively, the expression data set provides a comprehensive picture of human colonic epithelial cell differentiation. Our study also suggests that BMP antagonists are candidate signaling components that make up the intestinal epithelial stem cell niche." @default.
• W1995773697 created "2016-06-24" @default.
• W1995773697 creator A5004354054 @default.
• W1995773697 creator A5005384335 @default.
• W1995773697 creator A5007613197 @default.
• W1995773697 creator A5008045921 @default.
• W1995773697 creator A5016644714 @default.
• W1995773697 creator A5020214405 @default.
• W1995773697 creator A5028462736 @default.
• W1995773697 creator A5063856664 @default.
• W1995773697 creator A5065845168 @default.
• W1995773697 creator A5070945034 @default.
• W1995773697 creator A5080998067 @default.
• W1995773697 creator A5083687806 @default.
• W1995773697 date "2007-09-25" @default.
• W1995773697 modified "2023-10-11" @default.
• W1995773697 title "Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors" @default.
• W1995773697 cites W1536544150 @default.
• W1995773697 cites W1964322968 @default.
• W1995773697 cites W1965858634 @default.
• W1995773697 cites W1995060691 @default.
• W1995773697 cites W2007887290 @default.
• W1995773697 cites W2017593144 @default.
• W1995773697 cites W2017632960 @default.
• W1995773697 cites W2018173663 @default.
• W1995773697 cites W2023351030 @default.
• W1995773697 cites W2034034179 @default.
• W1995773697 cites W2042901535 @default.
• W1995773697 cites W2046881486 @default.
• W1995773697 cites W2050351042 @default.
• W1995773697 cites W2058169139 @default.
• W1995773697 cites W2066262186 @default.
• W1995773697 cites W2067526109 @default.
• W1995773697 cites W2067553572 @default.
• W1995773697 cites W2076534093 @default.
• W1995773697 cites W2089483555 @default.
• W1995773697 cites W2098278242 @default.
• W1995773697 cites W2102512718 @default.
• W1995773697 cites W2107648723 @default.
• W1995773697 cites W2109661968 @default.
• W1995773697 cites W2125459722 @default.
• W1995773697 cites W2154771406 @default.
• W1995773697 cites W2157795344 @default.
• W1995773697 cites W2166574880 @default.
• W1995773697 cites W2171996338 @default.
• W1995773697 cites W4242223477 @default.
• W1995773697 cites W4294107304 @default.
• W1995773697 doi "https://doi.org/10.1073/pnas.0707210104" @default.
• W1995773697 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2000506" @default.
• W1995773697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17881565" @default.
• W1995773697 hasPublicationYear "2007" @default.
• W1995773697 type Work @default.
• W1995773697 sameAs 1995773697 @default.
• W1995773697 citedByCount "486" @default.
• W1995773697 countsByYear W19957736972012 @default.
• W1995773697 countsByYear W19957736972013 @default.
• W1995773697 countsByYear W19957736972014 @default.
• W1995773697 countsByYear W19957736972015 @default.
• W1995773697 countsByYear W19957736972016 @default.
• W1995773697 countsByYear W19957736972017 @default.
• W1995773697 countsByYear W19957736972018 @default.
• W1995773697 countsByYear W19957736972019 @default.
• W1995773697 countsByYear W19957736972020 @default.
• W1995773697 countsByYear W19957736972021 @default.
• W1995773697 countsByYear W19957736972022 @default.
• W1995773697 countsByYear W19957736972023 @default.
• W1995773697 crossrefType "journal-article" @default.
• W1995773697 hasAuthorship W1995773697A5004354054 @default.
• W1995773697 hasAuthorship W1995773697A5005384335 @default.
• W1995773697 hasAuthorship W1995773697A5007613197 @default.
• W1995773697 hasAuthorship W1995773697A5008045921 @default.
• W1995773697 hasAuthorship W1995773697A5016644714 @default.
• W1995773697 hasAuthorship W1995773697A5020214405 @default.
• W1995773697 hasAuthorship W1995773697A5028462736 @default.
• W1995773697 hasAuthorship W1995773697A5063856664 @default.
• W1995773697 hasAuthorship W1995773697A5065845168 @default.
• W1995773697 hasAuthorship W1995773697A5070945034 @default.
• W1995773697 hasAuthorship W1995773697A5080998067 @default.
• W1995773697 hasAuthorship W1995773697A5083687806 @default.
• W1995773697 hasBestOaLocation W19957736971 @default.
• W1995773697 hasConcept C10116572 @default.
• W1995773697 hasConcept C104317684 @default.
• W1995773697 hasConcept C136302470 @default.
• W1995773697 hasConcept C137620995 @default.
• W1995773697 hasConcept C148738053 @default.
• W1995773697 hasConcept C153911025 @default.
• W1995773697 hasConcept C201750760 @default.
• W1995773697 hasConcept C28328180 @default.
• W1995773697 hasConcept C54355233 @default.
• W1995773697 hasConcept C62478195 @default.
• W1995773697 hasConcept C86803240 @default.
• W1995773697 hasConcept C95444343 @default.
• W1995773697 hasConceptScore W1995773697C10116572 @default.
• W1995773697 hasConceptScore W1995773697C104317684 @default.
• W1995773697 hasConceptScore W1995773697C136302470 @default.
• W1995773697 hasConceptScore W1995773697C137620995 @default.
• W1995773697 hasConceptScore W1995773697C148738053 @default.
• W1995773697 hasConceptScore W1995773697C153911025 @default.

• next