Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995782425> ?p ?o ?g. }
- W1995782425 endingPage "5533" @default.
- W1995782425 startingPage "5524" @default.
- W1995782425 abstract "Genomic recombination requires cutting, processing, and rejoining of DNA by endonucleases, polymerases, and ligases, among other factors. We have proposed that DNA recombination mechanisms may contribute to long-term memory (LTM) formation in the brain. Our previous studies with the nucleoside analog 1-β- d -arabinofuranosylcytosine triphosphate (ara-CTP), a known inhibitor of DNA ligases and polymerases, showed that this agent blocked consolidation of conditioned taste aversion without interfering with short-term memory (STM). However, because polymerases and ligases are also essential for DNA replication, it remained unclear whether the effects of this drug on consolidation were attributable to interference with DNA recombination or neurogenesis. Here we show, using C57BL/6 mice, that ara-CTP specifically blocks consolidation but not STM of context fear conditioning, a task previously shown not to require neurogenesis. The effects of a single systemic dose of cytosine arabinoside (ara-C) on LTM were evident as early as 6 h after training. In addition, although ara-C impaired LTM, it did not impair general locomotor activity nor induce brain neurotoxicity. Importantly, hippocampal, but not insular cortex, infusions of ara-C also blocked consolidation of context fear conditioning. Separate studies revealed that context fear conditioning training significantly induced nonhomologous DNA end joining activity indicative of DNA ligase-dependent recombination in hippocampal, but not cortex, protein extracts. Finally, unlike inhibition of protein synthesis, systemic ara-C did not block reconsolidation of context fear conditioning. Our results support the idea that DNA recombination is a process specific to consolidation that is not involved in the postreactivation editing of memories." @default.
- W1995782425 created "2016-06-24" @default.
- W1995782425 creator A5007182143 @default.
- W1995782425 creator A5041157832 @default.
- W1995782425 creator A5049022785 @default.
- W1995782425 creator A5050220924 @default.
- W1995782425 creator A5063350023 @default.
- W1995782425 creator A5065010513 @default.
- W1995782425 creator A5067952706 @default.
- W1995782425 creator A5078683542 @default.
- W1995782425 date "2006-05-17" @default.
- W1995782425 modified "2023-10-12" @default.
- W1995782425 title "An Inhibitor of DNA Recombination Blocks Memory Consolidation, But Not Reconsolidation, in Context Fear Conditioning" @default.
- W1995782425 cites W12880143 @default.
- W1995782425 cites W1485187747 @default.
- W1995782425 cites W1526397263 @default.
- W1995782425 cites W1567724025 @default.
- W1995782425 cites W1601515225 @default.
- W1995782425 cites W1608785134 @default.
- W1995782425 cites W1714203455 @default.
- W1995782425 cites W1805031383 @default.
- W1995782425 cites W1949317008 @default.
- W1995782425 cites W1963940970 @default.
- W1995782425 cites W1965420817 @default.
- W1995782425 cites W1968294508 @default.
- W1995782425 cites W1970937164 @default.
- W1995782425 cites W1975117208 @default.
- W1995782425 cites W1978488532 @default.
- W1995782425 cites W1980464924 @default.
- W1995782425 cites W1985155778 @default.
- W1995782425 cites W1986138698 @default.
- W1995782425 cites W1996855228 @default.
- W1995782425 cites W1998530321 @default.
- W1995782425 cites W1998859901 @default.
- W1995782425 cites W2004305039 @default.
- W1995782425 cites W2005744880 @default.
- W1995782425 cites W2009405131 @default.
- W1995782425 cites W2009823120 @default.
- W1995782425 cites W2013518271 @default.
- W1995782425 cites W2014238550 @default.
- W1995782425 cites W2014433545 @default.
- W1995782425 cites W2014821928 @default.
- W1995782425 cites W2017105911 @default.
- W1995782425 cites W2017544051 @default.
- W1995782425 cites W2017686829 @default.
- W1995782425 cites W2017841611 @default.
- W1995782425 cites W2018795098 @default.
- W1995782425 cites W2020553654 @default.
- W1995782425 cites W2025604203 @default.
- W1995782425 cites W2038496684 @default.
- W1995782425 cites W2038770029 @default.
- W1995782425 cites W2040198736 @default.
- W1995782425 cites W2040297259 @default.
- W1995782425 cites W2042042190 @default.
- W1995782425 cites W2042354688 @default.
- W1995782425 cites W2043985750 @default.
- W1995782425 cites W2045494953 @default.
- W1995782425 cites W2047165031 @default.
- W1995782425 cites W2048643743 @default.
- W1995782425 cites W2051472846 @default.
- W1995782425 cites W2052555812 @default.
- W1995782425 cites W2054017008 @default.
- W1995782425 cites W2054982643 @default.
- W1995782425 cites W2055324663 @default.
- W1995782425 cites W2055829187 @default.
- W1995782425 cites W2056291705 @default.
- W1995782425 cites W2060982272 @default.
- W1995782425 cites W2063055145 @default.
- W1995782425 cites W2079194017 @default.
- W1995782425 cites W2081831722 @default.
- W1995782425 cites W2082559835 @default.
- W1995782425 cites W2083258153 @default.
- W1995782425 cites W2087257090 @default.
- W1995782425 cites W2087984508 @default.
- W1995782425 cites W2089038077 @default.
- W1995782425 cites W2089206265 @default.
- W1995782425 cites W2089977417 @default.
- W1995782425 cites W2090849472 @default.
- W1995782425 cites W2095260142 @default.
- W1995782425 cites W2099405729 @default.
- W1995782425 cites W2102912401 @default.
- W1995782425 cites W2108678943 @default.
- W1995782425 cites W2109456034 @default.
- W1995782425 cites W2110570565 @default.
- W1995782425 cites W2111977586 @default.
- W1995782425 cites W2114653243 @default.
- W1995782425 cites W2122716676 @default.
- W1995782425 cites W2127919750 @default.
- W1995782425 cites W2131485156 @default.
- W1995782425 cites W2135039550 @default.
- W1995782425 cites W2136827845 @default.
- W1995782425 cites W2141841220 @default.
- W1995782425 cites W2142370758 @default.
- W1995782425 cites W2144983731 @default.
- W1995782425 cites W2145186621 @default.
- W1995782425 cites W2146070554 @default.
- W1995782425 cites W2146460558 @default.
- W1995782425 cites W2146631925 @default.