FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995782918> ?p ?o ?g. }

• W1995782918 endingPage "805" @default.
• W1995782918 startingPage "800" @default.
• W1995782918 abstract "Background The (pro)renin receptor exists in the kidney, blood vessels and the heart. (Pro)renin binds to the receptor and induces tissue injuries directly, completely independent of angiotensin II (Ang II). The renal renin–angiotensin–aldosterone system is activated in salt-sensitive hypertensive rats with in-vitro studies showing aldosterone increases angiotensin-converting enzyme (ACE) activity, renin production and angiotensin II type 1 receptor (AT1R) activity. However, the effect of blockade of mineralocorticoid receptor on the renal (pro)renin receptor, angiotensinogen, ACE and AT1R in Dahl salt-sensitive rats is unknown. Methods The following parameters were measured in Dahl salt-sensitive rats and in Dahl salt-resistant rats fed high-salt or low-salt diets and treated for 8 weeks with or without eplerenone (100 mg/kg per day, orally): blood pressure, plasma renin activity, plasma aldosterone concentration, kidney weight and Ang II contents, urinary protein excretion, glomerular injury (assessed by semiquantitative morphometric analysis) and levels of expression in the kidney of (pro)renin receptor protein and messenger RNA (mRNA) for angiotensinogen, ACE and AT1R. Results Dahl salt-sensitive rats fed a high-salt diet had increased kidney/body weight (175%) and urinary protein excretion (886%) and decreased plasma renin activity and plasma aldosterone concentration. The rats developed progressive sclerotic and proliferative glomerular changes, concomitant with increased expression of renal (pro)renin receptor protein and mRNA levels of angiotensinogen, ACE and AT1R and kidney Ang II content. Treatment with eplerenone in Dahl salt-sensitive rats was associated with significant improvements in kidney to body weight ratio, urinary protein excretion and renal injury scores and decreased renal (pro)renin receptor protein expression and angiotensinogen and AT1R mRNA levels and kidney Ang II content. Conclusion A high salt diet increased the renal renin–angiotensin system, whereas blockade of mineralocorticoid receptors attenuated renal injuries by decreasing the activity of tissue renin–angiotensin system in Dahl salt-sensitive rats." @default.
• W1995782918 created "2016-06-24" @default.
• W1995782918 creator A5001200637 @default.
• W1995782918 creator A5010374042 @default.
• W1995782918 creator A5015289084 @default.
• W1995782918 creator A5030978227 @default.
• W1995782918 creator A5032665333 @default.
• W1995782918 creator A5045375203 @default.
• W1995782918 creator A5065632340 @default.
• W1995782918 date "2009-04-01" @default.
• W1995782918 modified "2023-10-18" @default.
• W1995782918 title "Effect of mineralocorticoid receptor blockade on the renal renin–angiotensin system in Dahl salt-sensitive hypertensive rats" @default.
• W1995782918 cites W1964539892 @default.
• W1995782918 cites W1964833810 @default.
• W1995782918 cites W1967916526 @default.
• W1995782918 cites W1992315322 @default.
• W1995782918 cites W1996687450 @default.
• W1995782918 cites W2019310839 @default.
• W1995782918 cites W2024491849 @default.
• W1995782918 cites W2037030237 @default.
• W1995782918 cites W2048612808 @default.
• W1995782918 cites W2065895671 @default.
• W1995782918 cites W2070859361 @default.
• W1995782918 cites W2072372446 @default.
• W1995782918 cites W2086614658 @default.
• W1995782918 cites W2101948924 @default.
• W1995782918 cites W2106015949 @default.
• W1995782918 cites W2114271630 @default.
• W1995782918 cites W2114614037 @default.
• W1995782918 cites W2115932546 @default.
• W1995782918 cites W2116230802 @default.
• W1995782918 cites W2146227799 @default.
• W1995782918 cites W2147281302 @default.
• W1995782918 cites W2148155169 @default.
• W1995782918 cites W2150877212 @default.
• W1995782918 cites W2153396732 @default.
• W1995782918 cites W2165502965 @default.
• W1995782918 cites W2170424046 @default.
• W1995782918 cites W2172016508 @default.
• W1995782918 cites W4252397535 @default.
• W1995782918 doi "https://doi.org/10.1097/hjh.0b013e328325d861" @default.
• W1995782918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19516179" @default.
• W1995782918 hasPublicationYear "2009" @default.
• W1995782918 type Work @default.
• W1995782918 sameAs 1995782918 @default.
• W1995782918 citedByCount "36" @default.
• W1995782918 countsByYear W19957829182012 @default.
• W1995782918 countsByYear W19957829182013 @default.
• W1995782918 countsByYear W19957829182014 @default.
• W1995782918 countsByYear W19957829182015 @default.
• W1995782918 countsByYear W19957829182017 @default.
• W1995782918 countsByYear W19957829182018 @default.
• W1995782918 countsByYear W19957829182020 @default.
• W1995782918 countsByYear W19957829182021 @default.
• W1995782918 countsByYear W19957829182022 @default.
• W1995782918 crossrefType "journal-article" @default.
• W1995782918 hasAuthorship W1995782918A5001200637 @default.
• W1995782918 hasAuthorship W1995782918A5010374042 @default.
• W1995782918 hasAuthorship W1995782918A5015289084 @default.
• W1995782918 hasAuthorship W1995782918A5030978227 @default.
• W1995782918 hasAuthorship W1995782918A5032665333 @default.
• W1995782918 hasAuthorship W1995782918A5045375203 @default.
• W1995782918 hasAuthorship W1995782918A5065632340 @default.
• W1995782918 hasConcept C104849204 @default.
• W1995782918 hasConcept C123915805 @default.
• W1995782918 hasConcept C126322002 @default.
• W1995782918 hasConcept C134018914 @default.
• W1995782918 hasConcept C138976137 @default.
• W1995782918 hasConcept C170493617 @default.
• W1995782918 hasConcept C189135053 @default.
• W1995782918 hasConcept C198710026 @default.
• W1995782918 hasConcept C2776069600 @default.
• W1995782918 hasConcept C2778525890 @default.
• W1995782918 hasConcept C2780072264 @default.
• W1995782918 hasConcept C2780091579 @default.
• W1995782918 hasConcept C2908929049 @default.
• W1995782918 hasConcept C71924100 @default.
• W1995782918 hasConcept C84393581 @default.
• W1995782918 hasConceptScore W1995782918C104849204 @default.
• W1995782918 hasConceptScore W1995782918C123915805 @default.
• W1995782918 hasConceptScore W1995782918C126322002 @default.
• W1995782918 hasConceptScore W1995782918C134018914 @default.
• W1995782918 hasConceptScore W1995782918C138976137 @default.
• W1995782918 hasConceptScore W1995782918C170493617 @default.
• W1995782918 hasConceptScore W1995782918C189135053 @default.
• W1995782918 hasConceptScore W1995782918C198710026 @default.
• W1995782918 hasConceptScore W1995782918C2776069600 @default.
• W1995782918 hasConceptScore W1995782918C2778525890 @default.
• W1995782918 hasConceptScore W1995782918C2780072264 @default.
• W1995782918 hasConceptScore W1995782918C2780091579 @default.
• W1995782918 hasConceptScore W1995782918C2908929049 @default.
• W1995782918 hasConceptScore W1995782918C71924100 @default.
• W1995782918 hasConceptScore W1995782918C84393581 @default.
• W1995782918 hasIssue "4" @default.
• W1995782918 hasLocation W19957829181 @default.
• W1995782918 hasLocation W19957829182 @default.
• W1995782918 hasOpenAccess W1995782918 @default.
• W1995782918 hasPrimaryLocation W19957829181 @default.

• next