Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995792248> ?p ?o ?g. }
- W1995792248 endingPage "e35499" @default.
- W1995792248 startingPage "e35499" @default.
- W1995792248 abstract "Chronic infections resulting from biofilm formation are difficult to eradicate with current antimicrobial agents and consequently new therapies are needed. This work demonstrates that the carbon monoxide-releasing molecule CORM-2, previously shown to kill planktonic bacteria, also attenuates surface-associated growth of the gram-negative pathogen Pseudomonas aeruginosa by both preventing biofilm maturation and killing bacteria within the established biofilm. CORM-2 treatment has an additive effect when combined with tobramycin, a drug commonly used to treat P. aeruginosa lung infections. CORM-2 inhibited biofilm formation and planktonic growth of the majority of clinical P. aeruginosa isolates tested, for both mucoid and non-mucoid strains. While CORM-2 treatment increased the production of reactive oxygen species by P. aeruginosa biofilms, this increase did not correlate with bacterial death. These data demonstrate that CO-RMs possess potential novel therapeutic properties against a subset of P. aeruginosa biofilm related infections." @default.
- W1995792248 created "2016-06-24" @default.
- W1995792248 creator A5000436052 @default.
- W1995792248 creator A5020459221 @default.
- W1995792248 creator A5029651247 @default.
- W1995792248 creator A5032347914 @default.
- W1995792248 creator A5034436289 @default.
- W1995792248 creator A5064094344 @default.
- W1995792248 creator A5079894302 @default.
- W1995792248 date "2012-04-26" @default.
- W1995792248 modified "2023-10-05" @default.
- W1995792248 title "The Carbon Monoxide Releasing Molecule CORM-2 Attenuates Pseudomonas aeruginosa Biofilm Formation" @default.
- W1995792248 cites W1484225253 @default.
- W1995792248 cites W1546639195 @default.
- W1995792248 cites W1600690434 @default.
- W1995792248 cites W1940390013 @default.
- W1995792248 cites W1969044576 @default.
- W1995792248 cites W1978908521 @default.
- W1995792248 cites W1999046178 @default.
- W1995792248 cites W2026873843 @default.
- W1995792248 cites W2029009874 @default.
- W1995792248 cites W2034401433 @default.
- W1995792248 cites W2049800847 @default.
- W1995792248 cites W2050622608 @default.
- W1995792248 cites W2053850651 @default.
- W1995792248 cites W2055747781 @default.
- W1995792248 cites W2063405659 @default.
- W1995792248 cites W2070300719 @default.
- W1995792248 cites W2083352113 @default.
- W1995792248 cites W2087826558 @default.
- W1995792248 cites W2091990251 @default.
- W1995792248 cites W2094470927 @default.
- W1995792248 cites W2097924742 @default.
- W1995792248 cites W2106750536 @default.
- W1995792248 cites W2107016911 @default.
- W1995792248 cites W2121138686 @default.
- W1995792248 cites W2135397769 @default.
- W1995792248 cites W2136608718 @default.
- W1995792248 cites W2169118870 @default.
- W1995792248 cites W2170942810 @default.
- W1995792248 cites W2171898271 @default.
- W1995792248 doi "https://doi.org/10.1371/journal.pone.0035499" @default.
- W1995792248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3338523" @default.
- W1995792248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22563385" @default.
- W1995792248 hasPublicationYear "2012" @default.
- W1995792248 type Work @default.
- W1995792248 sameAs 1995792248 @default.
- W1995792248 citedByCount "53" @default.
- W1995792248 countsByYear W19957922482012 @default.
- W1995792248 countsByYear W19957922482013 @default.
- W1995792248 countsByYear W19957922482014 @default.
- W1995792248 countsByYear W19957922482015 @default.
- W1995792248 countsByYear W19957922482016 @default.
- W1995792248 countsByYear W19957922482017 @default.
- W1995792248 countsByYear W19957922482018 @default.
- W1995792248 countsByYear W19957922482019 @default.
- W1995792248 countsByYear W19957922482020 @default.
- W1995792248 countsByYear W19957922482021 @default.
- W1995792248 countsByYear W19957922482022 @default.
- W1995792248 countsByYear W19957922482023 @default.
- W1995792248 crossrefType "journal-article" @default.
- W1995792248 hasAuthorship W1995792248A5000436052 @default.
- W1995792248 hasAuthorship W1995792248A5020459221 @default.
- W1995792248 hasAuthorship W1995792248A5029651247 @default.
- W1995792248 hasAuthorship W1995792248A5032347914 @default.
- W1995792248 hasAuthorship W1995792248A5034436289 @default.
- W1995792248 hasAuthorship W1995792248A5064094344 @default.
- W1995792248 hasAuthorship W1995792248A5079894302 @default.
- W1995792248 hasBestOaLocation W19957922481 @default.
- W1995792248 hasConcept C185592680 @default.
- W1995792248 hasConcept C2777637488 @default.
- W1995792248 hasConcept C2778974779 @default.
- W1995792248 hasConcept C4937899 @default.
- W1995792248 hasConcept C501593827 @default.
- W1995792248 hasConcept C523546767 @default.
- W1995792248 hasConcept C54355233 @default.
- W1995792248 hasConcept C58123911 @default.
- W1995792248 hasConcept C86803240 @default.
- W1995792248 hasConcept C89423630 @default.
- W1995792248 hasConceptScore W1995792248C185592680 @default.
- W1995792248 hasConceptScore W1995792248C2777637488 @default.
- W1995792248 hasConceptScore W1995792248C2778974779 @default.
- W1995792248 hasConceptScore W1995792248C4937899 @default.
- W1995792248 hasConceptScore W1995792248C501593827 @default.
- W1995792248 hasConceptScore W1995792248C523546767 @default.
- W1995792248 hasConceptScore W1995792248C54355233 @default.
- W1995792248 hasConceptScore W1995792248C58123911 @default.
- W1995792248 hasConceptScore W1995792248C86803240 @default.
- W1995792248 hasConceptScore W1995792248C89423630 @default.
- W1995792248 hasIssue "4" @default.
- W1995792248 hasLocation W19957922481 @default.
- W1995792248 hasLocation W19957922482 @default.
- W1995792248 hasLocation W19957922483 @default.
- W1995792248 hasLocation W19957922484 @default.
- W1995792248 hasLocation W19957922485 @default.
- W1995792248 hasLocation W19957922486 @default.
- W1995792248 hasOpenAccess W1995792248 @default.
- W1995792248 hasPrimaryLocation W19957922481 @default.