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- W1995796027 abstract "to the standard immunosuppressive treatment demon-strating its limitations and the current unmet need of, at least, similarly effective and less toxic treatment. To illus-trate the close connection between a better understanding of the pathogenesis of the disease and targeted treatment, the papers on the pathogenesis of ANCA-associated vas-culitis [2], lupus nephritis [3], the role of anti-PLA2R an- tibodies [4] in membranous nephropathy and comple-ment in membranoproliferative glomerulonephritis [5] precede the articles dedicated to the treatment of second-ary [6–8] and primary glomerulonephritides [9–11]The . final contribution opens new horizons by reviewing the emerging biologic treatments [12] . We hope you enjoy this introduction to the complex area of the pathogenesis and targeted treatment of glo-merular disease and that this information will contribute to greater awareness, earlier diagnosis and referral, better treatment and improved outcome for patients with im-mune-mediated glomerular diseases. The classification of glomerular disease has been based almost entirely on renal histology, but an increasing un-derstanding of the pathogenesis is now introducing change relevant to the development of newer therapies. The introduction of corticosteroid and immunosuppres-sive drugs undoubtedly improved the outcome of patients with many forms of nephrotic syndrome, lupus nephritis and ANCA-associated vasculitis, but this non-specific treatment has been associated with serious short- and long-term toxicity, especially in patients with frequently relapsing disease. During the last 10 years, new biologic (targeted) treatment has expanded our therapeutic arma-mentarium, especially in refractory, relapsing or intoler-ant patients with ANCA-associated vasculitis, lupus ne-phritis and less commonly for other glomerular diseases.This special topic section of" @default.
- W1995796027 created "2016-06-24" @default.
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- W1995796027 date "2014-12-13" @default.
- W1995796027 modified "2023-10-15" @default.
- W1995796027 title "Biologic Treatment in Glomerular Disease" @default.
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- W1995796027 doi "https://doi.org/10.1159/000369646" @default.
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