Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995798553> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1995798553 endingPage "499" @default.
- W1995798553 startingPage "495" @default.
- W1995798553 abstract "Recently we have shown that cyanide poisoning by the oral (p.o.) route could be antagonized significantly by pretreatment or simultaneous treatment of alpha-ketoglutarate (alpha-KG), administered p.o. in rodents. The protective effect of alpha-KG was dose dependent (0.125-2.0 g kg(-1)) and the effect was significant at a dose above 1.0 g kg(-1). In order to establish the safety of alpha-KG, various haematological, biochemical and histological parameters were studied following p.o. administration of 2.0 g kg(-1)alpha-KG in female rats, and various physiological parameters were studied following p.o. administration of 2.0 or 4.0 g kg(-1)alpha-KG in anaesthetized male rats. The p.o. LD(50) of alpha-KG in male and female rats was >5.0 g kg(-1) and no toxic signs were observed in the surviving animals. Except for an increase in plasma alkaline phosphatase and urea levels after 1 h and a decrease in inorganic phosphorus levels after 7 days of treatment, no significant change in haematology, biochemistry or histology of the vital organs were observed. Mean arterial pressure and neuromuscular transmission were decreased at 4.0 g kg(-1)alpha-KG but other physiological variables such as heart rate, respiratory rate, rectal temperature, left ventricular pressure (systolic), arterial pressure (systolic) and arterial pressure (diastolic) were not altered. The changes observed at 4.0 g kg(-1)alpha-KG are unlikely to be of toxicological concern. The results indicate that alpha-KG at 2.0 g kg(-1) (p.o.)-a dose offering maximum antidotal efficacy-is non-toxic and therefore can be considered suitable for cyanide poisoning." @default.
- W1995798553 created "2016-06-24" @default.
- W1995798553 creator A5009558179 @default.
- W1995798553 creator A5031635319 @default.
- W1995798553 creator A5038164189 @default.
- W1995798553 creator A5040478048 @default.
- W1995798553 creator A5061527884 @default.
- W1995798553 creator A5085665278 @default.
- W1995798553 date "2001-01-01" @default.
- W1995798553 modified "2023-10-13" @default.
- W1995798553 title "Acute toxicity studies of ?-Ketoglutarate: a promising antidote for cyanide poisoning" @default.
- W1995798553 cites W1994523133 @default.
- W1995798553 cites W2002565670 @default.
- W1995798553 cites W2005681064 @default.
- W1995798553 cites W2008200322 @default.
- W1995798553 cites W2063965676 @default.
- W1995798553 cites W2094392602 @default.
- W1995798553 cites W4232301838 @default.
- W1995798553 doi "https://doi.org/10.1002/jat.786" @default.
- W1995798553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11746197" @default.
- W1995798553 hasPublicationYear "2001" @default.
- W1995798553 type Work @default.
- W1995798553 sameAs 1995798553 @default.
- W1995798553 citedByCount "13" @default.
- W1995798553 countsByYear W19957985532012 @default.
- W1995798553 countsByYear W19957985532013 @default.
- W1995798553 countsByYear W19957985532016 @default.
- W1995798553 countsByYear W19957985532021 @default.
- W1995798553 crossrefType "journal-article" @default.
- W1995798553 hasAuthorship W1995798553A5009558179 @default.
- W1995798553 hasAuthorship W1995798553A5031635319 @default.
- W1995798553 hasAuthorship W1995798553A5038164189 @default.
- W1995798553 hasAuthorship W1995798553A5040478048 @default.
- W1995798553 hasAuthorship W1995798553A5061527884 @default.
- W1995798553 hasAuthorship W1995798553A5085665278 @default.
- W1995798553 hasConcept C126322002 @default.
- W1995798553 hasConcept C134018914 @default.
- W1995798553 hasConcept C140793950 @default.
- W1995798553 hasConcept C141071460 @default.
- W1995798553 hasConcept C160160445 @default.
- W1995798553 hasConcept C181199279 @default.
- W1995798553 hasConcept C185592680 @default.
- W1995798553 hasConcept C194409129 @default.
- W1995798553 hasConcept C2775944032 @default.
- W1995798553 hasConcept C2777953023 @default.
- W1995798553 hasConcept C2779365888 @default.
- W1995798553 hasConcept C29730261 @default.
- W1995798553 hasConcept C49453240 @default.
- W1995798553 hasConcept C55493867 @default.
- W1995798553 hasConcept C64943373 @default.
- W1995798553 hasConcept C71924100 @default.
- W1995798553 hasConcept C8213797 @default.
- W1995798553 hasConcept C84393581 @default.
- W1995798553 hasConcept C86803240 @default.
- W1995798553 hasConceptScore W1995798553C126322002 @default.
- W1995798553 hasConceptScore W1995798553C134018914 @default.
- W1995798553 hasConceptScore W1995798553C140793950 @default.
- W1995798553 hasConceptScore W1995798553C141071460 @default.
- W1995798553 hasConceptScore W1995798553C160160445 @default.
- W1995798553 hasConceptScore W1995798553C181199279 @default.
- W1995798553 hasConceptScore W1995798553C185592680 @default.
- W1995798553 hasConceptScore W1995798553C194409129 @default.
- W1995798553 hasConceptScore W1995798553C2775944032 @default.
- W1995798553 hasConceptScore W1995798553C2777953023 @default.
- W1995798553 hasConceptScore W1995798553C2779365888 @default.
- W1995798553 hasConceptScore W1995798553C29730261 @default.
- W1995798553 hasConceptScore W1995798553C49453240 @default.
- W1995798553 hasConceptScore W1995798553C55493867 @default.
- W1995798553 hasConceptScore W1995798553C64943373 @default.
- W1995798553 hasConceptScore W1995798553C71924100 @default.
- W1995798553 hasConceptScore W1995798553C8213797 @default.
- W1995798553 hasConceptScore W1995798553C84393581 @default.
- W1995798553 hasConceptScore W1995798553C86803240 @default.
- W1995798553 hasIssue "6" @default.
- W1995798553 hasLocation W19957985531 @default.
- W1995798553 hasLocation W19957985532 @default.
- W1995798553 hasOpenAccess W1995798553 @default.
- W1995798553 hasPrimaryLocation W19957985531 @default.
- W1995798553 hasRelatedWork W1970537717 @default.
- W1995798553 hasRelatedWork W1975506238 @default.
- W1995798553 hasRelatedWork W2350692079 @default.
- W1995798553 hasRelatedWork W2391642370 @default.
- W1995798553 hasRelatedWork W2409552309 @default.
- W1995798553 hasRelatedWork W2529508190 @default.
- W1995798553 hasRelatedWork W2568088706 @default.
- W1995798553 hasRelatedWork W3127792877 @default.
- W1995798553 hasRelatedWork W3160708701 @default.
- W1995798553 hasRelatedWork W3089044989 @default.
- W1995798553 hasVolume "21" @default.
- W1995798553 isParatext "false" @default.
- W1995798553 isRetracted "false" @default.
- W1995798553 magId "1995798553" @default.
- W1995798553 workType "article" @default.