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- W1995804923 abstract "As a first step to understand preimplantation development, we performed global gene-expression profiling of morula and blastocyst using the NIA 15k mouse cDNA microarray. Gene expression levels were measured four times for blastocyst and five times for morula. Student's t-test at the 5% significance level identified 428 genes upregulated and 748 downregulated in blastocyst compared to morula. This trend was consistent with semi-quantative RT-PCR analysis of sample genes. The upregulated genes known to be involved in critical regulatory processes, included Mist1, Id2, Hd1, and Requiem; the downregulated genes included CREB-binding protein, Per3, zinc finger protein 217, Krox-25, and miwi1. Such well-characterized genes and many novel genes provide markers for early stages in development and starting materials for further functional studies." @default.
- W1995804923 created "2016-06-24" @default.
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- W1995804923 date "2004-07-01" @default.
- W1995804923 modified "2023-09-25" @default.
- W1995804923 title "A global view of gene expression in the preimplantation mouse embryo: morula versus blastocyst" @default.
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- W1995804923 doi "https://doi.org/10.1016/j.ejogrb.2004.01.026" @default.
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