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- W1995807744 abstract "• Four patients experienced combined sickle cell disease and autoimmune hemolytic anemia within the past ten years. A fifth patient had positive direct antiglobulin test results without verified autoimmune hemolysis. Severely accelerated hemolysis was observed in four patients; anemia was severe, and the reticulocyte count rose into the 60% to 88% range. During the period of active autoimmune hemolysis, decline of the reticulocyte count into the 6% to 16% range was associated with rapid decrease in the hemoglobin level, requiring transfusion. All five patients were already alloimmunized by transfusions administered before onset of the autoimmune hemolytic anemia; two or more allospecificities were identified in four of five patients. The presence of autoantibody notably compromised compatibility testing; three patients experienced posttransfusion hemoglobinuria, and in vivo cross matching with<sup>51</sup>Cr-labeled donor RBCs was employed on three occasions. All patients responded to corticosteroids; mercaptopurine was also administered to one patient. The direct antiglobulin test result reverted to negative in all patients after hospital discharge. (<i>Arch Intern Med</i>1981;141:1091-1093)" @default.
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- W1995807744 date "1981-07-01" @default.
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- W1995807744 title "Combined Sickle Cell Disease and Autoimmune Hemolytic Anemia" @default.
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- W1995807744 doi "https://doi.org/10.1001/archinte.1981.00340080127029" @default.
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